Evidence map›Paper›PMID 41728646›Full record

ArticleInternational journal of immunopathology and pharmacology

Agmatine suppresses the imidazoline I

Linguo Bai, Kun Yu, Qiuyu Dai, Jie Zheng, Kangjie Qin, Junjie Li, Feiyan Li, Song Qin, Hong Mei, Xinxin Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Linguo BaiDepartment of Neurosurgery, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Kun YuDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Qiuyu DaiZunyi Medical University, Zunyi, Guizhou, China.
Jie ZhengDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Kangjie QinDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Junjie LiDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Feiyan LiDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Song QinDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Hong MeiDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.ORCID 0000-0001-8848-5580
Xinxin LiuDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Tao ChenDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Liting ChengDepartment of Critical Care Medicine, Kweichow Moutai Hospital, Renhuai, Guizhou, China.ORCID 0009-0001-4547-1901

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute respiratory distress syndrome (ARDS) is an acute diffuse inflammatory lung injury characterized by damage to alveolar epithelial cells and pulmonary capillary endothelial cells. Compared with ARDS caused by other causes, the subtypes of ARDS caused by sepsis are more serious and lead to poor prognosis and higher mortality. Agmatine (AGM) is a biological metabolite of L-arginine decarboxylation, proven to ameliorate sepsis-induced acute lung injury (SALI), but the mechanism remains unclear. Therefore, this study aims to explore the role of AGM in SALI, clarify the relationship between the I

Indexed as

Acute Lung InjuryAgmatineImidazoline ReceptorsMacrophages, AlveolarNF-kappa BSepsisAnimalsDisease Models, AnimalLipopolysaccharidesMaleMiceMice, Inbred C57BLSignal TransductionAgmatineImidazoline ReceptorsLipopolysaccharidesNF-kappa Bacute lung injuryagmatinemacrophage polarizationsepsis

Identifiers

PMID41728646
PMCPMC12929822

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.