SynthesisFrontiers in medicine2026
Impact of different anesthetics on ischemia reperfusion injuries in patients undergoing hepatectomy: a network meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hepatectomy, a commonly employed surgical approach for treating liver-related disorders, has emerged as the primary method for the radical treatment of early stage liver cancer. This network meta-analysis was conducted to evaluate the impacts of different anesthetics on ischemia reperfusion injuries in patients undergoing hepatectomy. Methods: Randomized controlled trials (RCTs) and cohort studies were identified through searches in four databases, PubMed, Embase, the Cochrane Library, and the Web of Science, up to February 12, 2025. Non-English studies were excluded, and this study was conducted in compliance with PRISMA-NMA guidelines. Bayesian network meta-analysis was employed based on the R 4.3.2 and Stata 15.1. The efficacy of each intervention was evaluated through SUCRA (surface under the cumulative ranking curve). Results: The analysis included 19 studies with a total of 1,319 participants. In terms of reducing aspartate transaminase (AST) levels, the combination of propofol and sevoflurane exhibited the highest effectiveness (SUCRAs: 71.82%), followed by the combination of propofol, isoflurane, and fentanyl (SUCRAs: 61.87%), and sevoflurane monotherapy (SUCRAs: 58.61%). The combination of propofol and sevoflurane (SUCRAs: 71.94%) ranked first for reducing ALT levels, followed by propofol monotherapy (SUCRAs: 61.71%) and the combination of propofol and sufentanil (SUCRAs: 58.59%). Conclusion: The combination of propofol and sevoflurane appear to be the most effective approach for reducing AST and ALT levels. This combination could serve as a favorable anesthetic strategy to limit hepatic enzyme elevations after hepatectomy, thus supporting liver function protection. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/home, identifier CRD42023472070.
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