ReviewCureus2026
Layered Management of Hypertrophic Scars and Keloids: From Silicone and Intralesional Triamcinolone Acetonide Plus 5-Fluorouracil to Adjuvant Strontium-90.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertrophic scars and keloids are fibroproliferative scars that can cause disfigurement, pruritus, pain, contracture, and reduced quality of life. Outcomes remain inconsistent because phenotypes vary by anatomic site, thickness, skin type, and time since injury, and no single modality is uniformly curative. We performed a narrative review informed by a structured search of MEDLINE/PubMed, Embase, Cochrane Library, Web of Science, and Scopus (2000 to November 2025), including clinical trials, observational studies, systematic reviews, and consensus guidance with clinically actionable treatment parameters. Evidence most consistently supports early, low-risk modulation with silicone gel or sheets for the prevention and early treatment of hypertrophic scars. For established hypertrophic scars and keloids, intralesional triamcinolone acetonide combined with 5-fluorouracil provides a practical pharmacological backbone, offering more reliable flattening and symptom control than steroid monotherapy. Adjuncts should be selected according to dominant clinical features, including cryotherapy for relatively thin lesions, fractional carbon dioxide laser for thickness and texture, and botulinum toxin A when tension, pruritus, or contracture is prominent. For selected thin keloids, radiotherapy options include external beam techniques and brachytherapy; superficial beta-brachytherapy with strontium-90 may serve as consolidation after response to intralesional therapy or as targeted postoperative adjuvant at high-risk sites. Because pigmentary adverse effects are clinically important in darker skin types, procedural choices should incorporate explicit counseling and conservative parameters. A pragmatic algorithm, reassessment triggers, and a modality summary table are provided to support routine clinical decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.