ArticleCureus2026
Postoperative Pain Profiles Associated With Pre-incisional Intravenous Paracetamol or Port-Site Infiltration of 0.5% Ropivacaine in Laparoscopic Cholecystectomy: An Observational Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to describe and compare postoperative pain patterns associated with two commonly used pre-incisional analgesic practices: intravenous paracetamol and port-site infiltration of 0.5% ropivacaine in patients undergoing laparoscopic cholecystectomy. METHODOLOGY: This observational study included 68 adult patients undergoing elective laparoscopic cholecystectomy under general anesthesia between December 2019 and April 2021. Ethical approval was obtained, and informed consent was secured from all participants. According to routine anesthetic practice, patients received either pre-incisional intravenous paracetamol (Group P, n = 34 (50%)) or port-site infiltration with 0.5% ropivacaine (Group R, n = 34 (50%)). Postoperative pain was assessed using the visual analog scale (VAS) at defined postoperative time points, and the need for rescue analgesia and the incidence of postoperative nausea and vomiting (PONV) were recorded.
resultsA total of 68 patients were analyzed, with comparable baseline characteristics between the intravenous paracetamol and port-site ropivacaine groups (mean age 42.5 ± 12.2 years; females 64.7%). Postoperative pain was observed in 48 (70.6%) patients, with a similar distribution between the two groups. Mean VAS scores declined from 7.55 ± 0.75 at 0 hour to 3.15 ± 1.4 at 24 hours in both groups. Rescue analgesia within 24 hours was required in 30 (44.1%) patients, more frequently in the intravenous paracetamol group (58.8%) than the port-site ropivacaine group (29.4%). Logistic regression showed higher, but non-significant, odds of rescue analgesia with intravenous paracetamol (OR 2.25; 95% CI 0.92-5.50).
conclusionPre-incisional intravenous paracetamol combined with port-site infiltration of ropivacaine produces a predictable postoperative pain trajectory following laparoscopic cholecystectomy. Although the specific effect of port-site ropivacaine on local incision pain could not be isolated, the intervention contributes to overall pain control. No clear predictors of rescue analgesia were identified. These findings highlight the importance of incorporating site-specific analgesia into a broader multimodal pain management strategy to optimize postoperative comfort.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.