ArticleCureus2026
Comparative Evaluation of Intraperitoneal Instillation of Bupivacaine With Magnesium Sulfate Versus Bupivacaine With Dexmedetomidine for Postoperative Relief After Laparoscopic Cholecystectomy.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLaparoscopic cholecystectomy (LC) is the most common surgical treatment for cholelithiasis and offers advantages over open surgery. However, postoperative pain remains a significant concern, arising from both somatic and visceral components. Intraperitoneal instillation of local anesthetics with adjuvants has been explored as a simple and effective method of pain control.
objectiveThis study compared intraperitoneal bupivacaine with magnesium sulfate versus bupivacaine with dexmedetomidine for postoperative pain relief in LC. Pain assessed using the Visual Analog Scale (VAS), analgesia duration, rescue analgesic use, and hemodynamic stability were evaluated. MATERIALS AND
methodsA prospective, randomized, double-blind clinical study was conducted on 116 American Society of Anesthesiologists I and II patients undergoing elective LC. Patients were divided into two groups: Group A received intraperitoneal bupivacaine with magnesium sulfate, and Group B received intraperitoneal bupivacaine with dexmedetomidine. Pain scores, analgesic duration, rescue analgesic requirement, and hemodynamic parameters were compared between the groups.
resultsBoth groups were comparable with respect to demographic variables. Group A showed significantly lower VAS scores at two, four, and six hours postoperatively (p < 0.001), indicating better early pain control. The duration of analgesia and total rescue analgesic consumption were comparable between groups. Hemodynamic parameters were stable, though Group B exhibited lower heart rate and blood pressure at some time intervals, consistent with the sympatholytic effect of dexmedetomidine. Both regimens were well tolerated, with minimal side effects.
conclusionsIntraperitoneal instillation of bupivacaine with magnesium sulfate provides superior early postoperative analgesia compared to bupivacaine with dexmedetomidine, while both combinations are safe and effective. Magnesium sulfate is a cost-effective, readily available adjuvant that may be considered a better alternative in multimodal analgesia for LC.
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