Evidence map›Paper›PMID 41728498›Full record

ReviewCureus2026

From Anxiety, Depression to Major Neurocognitive Disorders: Exploring Their Association With the Risk Factors for Dementia.

Ali A Sulais, Nada Al Zamil

Abstract readReview
In one paragraph

Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ali A SulaisChild and Adolescent Psychiatry, McGill University, Montréal, CAN.
Nada Al ZamilPsychiatry, King Fahad University Hospital, Khobar, SAU.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dementia presents an escalating public health challenge worldwide. While traditional risk factors such as metabolic syndromes and lifestyle choices have been widely examined, growing evidence highlights the role of mental health conditions in the development of dementia. Our manuscript is a narrative review of peer-reviewed systematic reviews and meta-analyses examining the association between common psychiatric disorders, namely depression, bipolar disorder, anxiety, post traumatic stress disorder (PTSD), schizophrenia, and the onset of neurocognitive decline. Additional factors such as chronic stress, sleep disturbances, and exposure to traumatic life events are also considered. Proposed mechanisms include endocrine dysregulation, neuroinflammation, and altered immune responses. The review further explores how psychopharmacological interventions may influence cognitive outcomes later in life. These insights aim to enhance clinicians' ability to identify at-risk populations and inform preventive strategies.

Indexed as

dementia neurodegenerationdementia preventionneurocognitive disorderspsychiatric disorders neurologic diseasespsychotropic medications

Identifiers

PMID41728498
PMCPMC12922723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.