Evidence map›Paper›PMID 41728489›Full record

ArticleCureus2026

Falling Off the Growth Curve: An Underrecognized Risk of Automated Formula Machines.

Evan S Baker, Neemesh Desai, Lucas McKnight

Abstract readCase Reports
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Evan S BakerInternal Medicine-Pediatrics, The Ohio State University College of Medicine, Columbus, USA.
Neemesh DesaiInternal Medicine-Pediatrics, The Ohio State University Wexner Medical Center and Nationwide Children's Hospital, Columbus, USA.
Lucas McKnightInternal Medicine, The Ohio State University Wexner Medical Center and Nationwide Children's Hospital, Columbus, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growth faltering, falling off the growth curve, or failure to thrive are all common terms used to describe a frequent but clinically important scenario routinely seen in pediatrics, often identified during infancy and other periods of rapid growth. Inadequate intake is the most common cause identified, especially in the neonatal period. This can lead to lasting consequences for cognitive potential and final adult height. We present the case of a four-month-old female infant who experienced a sudden decline from the 13.6th to the 4.6th percentile in weight for age between six weeks of age and her four-month well visit. Parents reported an adequate intake volume of 32 oz/day prepared with an automated formula machine and age-appropriate elimination. A careful nutrition history regarding formula preparation revealed that the machine was set to a concentration significantly lower than recommended for her specific formula. This meant the prepared formula provided substantially fewer than the recommended 20 kcal/oz. After two weeks of manual formula fortification, the patient demonstrated improved weight gain and returned to the 14.72nd percentile in weight for age. While growth faltering is common, this report highlights a less frequently recognized cause of inadequate intake, namely, improperly concentrated formula prepared by an automated mixing machine. This underscores the importance of a thorough pediatric nutrition history, including a detailed assessment of formula mixing methods. Physicians must be prepared to counsel caregivers on correct formula preparation, whether using manual or automated mixing methods. With automated machines, providers should consider verifying that the settings are appropriate for the specific formula. When patients present with inadequate growth, it is important to consider incorrect formula preparation as a potential etiology and to investigate further.

Indexed as

automated formula machinesfailure-to-thriveformulaformula-fedgrowth curvegrowth falteringmanual vs automationnutritionnutrition assessmentpoor weight gain

Identifiers

PMID41728489
PMCPMC12924704

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.