Anticancer potential of fused heterocycles: structural insights and mechanistic advances.

Aaysha Pandey, Shubham Sharma, Kamal Kishore, Swati Rani, Man Vir Singh, Gangotri Pemawat

Abstract read

In one paragraph

Article in Asian biomedicine : research, reviews and news, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Diethylene Glycol-Linked Ring-Fused Bis-Azoles: Target-Oriented Synthesis, In Silico Screening, and Antitumor Activity.ChemMedChem · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aaysha PandeySchool of Allied Sciences, Department of Chemistry, Dev Bhoomi Uttarakhand University, Dev Bhoomi Campus, Dehradun Uttarakhand 248007, India.

Shubham SharmaOrganic Synthesis Research Laboratory, Department of Chemistry, GLA University, Mathura, Uttar Pradesh 281406, India shubham.sharma@gla.ac.in.

Kamal KishoreSchool of Civil, Mining, Environmental and Architectural Engineering, Department of Civil Engineering, University of Wollongong, Wollongong, New South Wales 2500, Australia.

Swati RaniDepartment of Chemistry, Miranda House, University of Delhi, Delhi 110001, India.

Man Vir SinghSchool of Allied and Life Science, UIT, Uttaranchal University, Dehradun 248007, India.

Gangotri PemawatDepartment of Chemistry, Mohanlal Sukhadia University, Udaipur, Rajasthan 313001, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β-lactam derivatives, carbazoles, isatin derivatives, pyrrolo-benzodiazepines (PBDs), and pyrido[2,3-d]pyrimidines have demonstrated potential as anticancer agents among organic compounds. They exhibit substantial anticancer efficacy across several cancer cell lines, such as HL-60, THP-1, U-937, HeLa, PANC1, MDA-MB-231, and A549 cell lines. These compounds display a significant anticancer profile via diverse biological pathways such as DNA interaction, kinase inhibition, microtubule disruption, and enzyme inhibition. Their low IC50 values across various cell lines suggest their viability as strong candidates for targeted and multi-mechanistic cancer therapy, warranting further in vivo and clinical exploration. This review thoroughly summarized the anticancer efficacy of

Indexed as

anti-cancercarbazoleisatinpyrido[2,3-d]pyrimidinepyrrolo-benzodiazepineβ- lactam

Identifiers

PMID41728367

DOI10.2478/abm-2025-0035

PMCPMC12919380

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.