Evidence map›Paper›PMID 41728352›Full record

ArticleOncology letters2026

Potential treatment benefits of a GLP-1R antagonist in combination with immune checkpoint inhibitors in colorectal cancer.

Zengqin Zhan, Chuncha Zhan, Lianqiao Li, Dan Lan, Guya Meng, Fan Chen

Abstract read
In one paragraph

Article in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zengqin ZhanDepartment of Oncology, Guangzhou Development District Hospital, Guangzhou, Guangdong 510700, P.R. China.
Chuncha ZhanDepartment of General Practice, Tianyuan Community Health Service Center, Tianhe, Guangzhou, Guangdong 510000, P.R. China.
Lianqiao LiDepartment of Oncology, Guangzhou Development District Hospital, Guangzhou, Guangdong 510700, P.R. China.
Dan LanDepartment of Oncology, Guangzhou Development District Hospital, Guangzhou, Guangdong 510700, P.R. China.
Guya MengDepartment of Oncology, People's Hospital of Sandu County, Guizhou 558100, P.R. China.
Fan ChenDepartment of Oncology, Guangzhou Development District Hospital, Guangzhou, Guangdong 510700, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical efficacy of immune checkpoint inhibitors (ICIs) in colorectal cancer (CRC) remains limited. Modulation of the glucagon-like peptide-1 receptor (GLP-1R) may enhance T-cell-mediated antitumor responses. The present study aimed to evaluate the antitumor effects of the GLP-1R antagonist Exendin 9-39 (Exe-9) combined with anti-programmed cell death protein-1 (PD-1) treatment in preclinical CRC models. Using

Indexed as

colorectal cancerExendin 9–39glucagon-like peptide-1 receptorimmune checkpoint inhibitorsT-cell-mediated cytotoxicity

Identifiers

PMID41728352
PMCPMC12917479

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.