ArticlemedRxiv : the preprint server for health sciences2026
Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of risk.
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Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
41 authors.
Aubrey K HubbardDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0003-4052-1110
Hélène Neyret-KahnINSERM U1330, Children's Oncology Research Unit, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris 75005, France.ORCID 0000-0002-5660-4941
Martina Müller-NurasiydInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Dominik LöwInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Konstantin StrauchInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Olivia W LeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-3199-3004
Andrew R RaduskiDivision of Pediatric Epidemiology & Clinical Research, Pediatrics Department, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-7069-6934
Tianzhong YangDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-0162-7740
Weiyin ZhouDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-0467-3064
Elliot W StrattonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Orson JayINSERM U1330, Children's Oncology Research Unit, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris 75005, France.
Sandrine GrossetêteINSERM U1330, Children's Oncology Research Unit, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris 75005, France.
Andrew J SongDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Diptavo DuttaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-6634-9040
Amy A HutchinsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Belynda D HicksDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Michelle ManningDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Jia LiuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Carrie BoyceWestat, Rockville, MD, USA.
Wolfgang HartmannGerhard-Domagk-Institute of Pathology, Münster University Hospital, Münster, Germany.
Uta DirksenPediatrics III, West German Cancer Center, National Center for Tumor Diseases (NCT). West, German Cancer Consortium (DKTK) site Essen, University Hospital Essen, Essen, Germany.
Andreas E KulozikDepartment of Pediatric Oncology, Hematology and Immunology, Heidelberg University, Clinical Cooperation Unit Pediatric Leukemia, German Cancer Research Center (DKFZ).
Markus MetzlerDepartment of Paediatrics and Adolescent Medicine, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Manuela KrumbholzInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Alexander TeumerDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-8309-094X
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany and DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
Joshua D SchiffmanDepartments of Pediatrics and Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-6968-7694
Javed KhanCenter for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Melissa M HudsonDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-6984-2407
Kirsten K NessDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.
Zhaoming WangDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.
Katherine A JanewayDana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.ORCID 0000-0001-6000-3594
Philip J LupoAflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta/Department of Pediatrics, Emory University, Atlanta, GA, USA.ORCID 0000-0003-0978-5863
Logan G SpectorDivision of Pediatric Epidemiology & Clinical Research, Pediatrics Department, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-2516-0222
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Steven C MooreDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-2324-3393
Thomas G P GrünewaldHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Olivier DelattreINSERM U1330, Children's Oncology Research Unit, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris 75005, France.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0001-6538-9705
Funding
WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6MNCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6MCOG U24 Funding 2026-2027U24CA196173 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI Mignon Lee-Cheun Loh, Nilsa Del Carmen Ramirez Milan · 2015 to 2026
$62.5MThe St. Jude Lifetime CohortU01CA195547 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HUDSON, MELISSA M, NESS, KIRSTEN KIMBERLIE · 2015 to 2024
$14.9MGenetic pleiotropy across pediatric cancers, and cancer-related outcomesR01CA283333 · NCI · UNIVERSITY OF MINNESOTA · PI Cindy Im · 2024 to 2026
$2.2MNCI NIH HHS R01 CA283333NCI NIH HHS U01 CA195547NCI NIH HHS U10 CA180886NCI NIH HHS U24 CA196173NIH HHS 75N91019D00024
Abstract
Ewing sarcoma (EwS) is a rare, aggressive pediatric malignancy driven by
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.