Evidence map›Paper›PMID 41728329›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Genomic insights into substance use and disinhibitory disorders.

Camille M Williams, Holly E Poore, Diego Londono-Correa, Yuchen Ning, Natasia S Courchesne-Krak, Maia Choi, Justin D Tubbs, Matthew Rosenblatt, Peter T Tanksley, Fazil Aliev and 28 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Camille M WilliamsLaboratoire de Sciences Cognitives et Psycholinguistique, Département d'Études Cognitives, École Normale Supérieure, EHESS, CNRS, PSL University, Paris, France.ORCID 0000-0002-1471-6566
Holly E PooreDepartment of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.
Diego Londono-CorreaDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
Yuchen NingDepartment of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands.
Natasia S Courchesne-KrakDepartment of Psychiatry, University of California, San Diego, CA, USA.
Maia ChoiRutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ, USA.
Justin D TubbsCenter for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-6671-6816
Matthew RosenblattCenter for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Peter T TanksleyALERRT Center, Texas State University, San Marcos, TX, USA.
Fazil AlievDepartment of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.
Nathaniel Y BellDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-0543-5623
Joseph D DeakDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0540-6080
Jean GonzalezDepartment of Psychiatry, University of California, San Diego, CA, USA.
Mariela JenningsDepartment of Psychiatry, University of California, San Diego, CA, USA.
Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Tanya N PhungDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Marijn SchipperDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Ronald de VlamingDepartment of Econometrics and Data Science, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Kai YuanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Boston, MA, USA.
Hang ZhouDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Emily BalckeDepartment of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.
Sarah J BrislinDepartment of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.
COGA Collaborators
Javier de la FuenteDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
Michael J GandalLifespan Brain Institute at Penn Med and the Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
Tian GeCenter for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Joel GelernterDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4067-1859
Danielle PosthumaDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Jordan W SmollerCenter for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Elliot M Tucker-DrobDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
Irwin D WaldmanDepartment of Psychology, Emory University, Atlanta, GA, USA.
Abraham A PalmerDepartment of Psychiatry, University of California, San Diego, CA, USA.ORCID 0000-0003-3634-0747
Peter B BarrDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA.ORCID 0000-0001-9321-657X
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California, San Diego, CA, USA.
Richard Karlsson LinnérDepartment of Economics, Leiden Law School, Universiteit Leiden, Leiden, The Netherlands.ORCID 0000-0001-7839-2858
Danielle M DickDepartment of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.
K Paige HardenDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
Travis T MallardCenter for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7M
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Wave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1M
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
BLRD VA I01 BX006482NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHGRI NIH HHS T32 HG010464NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006378NHLBI NIH HHS U19 HL065962NIAAA NIH HHS L40 AA031140NIAAA NIH HHS P50 AA022537NIAAA NIH HHS R01 AA015416NIAAA NIH HHS T32 AA032229NIAAA NIH HHS U10 AA008401NIA NIH HHS P30 AG066614NIA NIH HHS R01 AG073593NICHD NIH HHS P01 HD031921NICHD NIH HHS P2C HD042849NICHD NIH HHS R01 HD060726NICHD NIH HHS R01 HD073342NICHD NIH HHS R01 HD074711NICHD NIH HHS R01 HD092548NICHD NIH HHS R01 HD114721NIDA NIH HHS DP1 DA054394NIDA NIH HHS K01 DA051759NIDA NIH HHS K01 DA058807NIDA NIH HHS K01 DA059657NIDA NIH HHS K23 DA058808NIDA NIH HHS P30 DA060810NIDA NIH HHS R01 DA050721NIDA NIH HHS R01 DA058862NIDA NIH HHS R01 DA061977NIDA NIH HHS T32 DA055569NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIGMS NIH HHS P50 GM115305NIGMS NIH HHS RC2 GM092618NIMHD NIH HHS U54 MD017979NIMH NIH HHS K01 MH141330NIMH NIH HHS K08 MH135343NIMH NIH HHS R01 MH120219NINDS NIH HHS R01 NS032830
6 · The paper itself

Abstract

Externalizing spectrum disorders-spanning attention-deficit/hyperactivity disorder, conduct disorder, substance use disorders, and other disorders characterized by disinhibition-frequently co-occur within individuals due, in part, to shared genetic etiology. To advance understanding of this genetic architecture, we conducted a multi-ancestry, multivariate genome-wide association analysis of more than 4 million individuals, identifying 1,294 genomic regions linked to an externalizing factor. Fine-mapping and gene prioritization efforts identified 961 effector genes, with the putative causal variant associations showing robust replication in the All of Us Research Program sample. Bioinformatic analyses revealed a broadly distributed neural architecture with early and sustained involvement of GABAergic and glutamatergic neurons. Drug repurposing analyses further highlighted the role of GABA

Identifiers

PMID41728329
PMCPMC12919125

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.