Evidence map›Paper›PMID 41728324›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Abnormal hippocampo-cortical theta-gamma phase-amplitude coupling in Alzheimer's disease.

Erfan Baradarantohidi, Srikantan S Nagarajan, Kamalini G Ranasinghe, Stefan Haufe

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Erfan BaradarantohidiTechnische Universität Berlin, 10623 Berlin, Germany.ORCID 0009-0001-8406-4401
Srikantan S NagarajanDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0001-7209-3857
Kamalini G RanasingheMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0002-4217-8785
Stefan HaufeTechnische Universität Berlin, 10623 Berlin, Germany.ORCID 0000-0003-1470-9195

Funding

Understanding disorder-specific neural pathophysiology in laryngeal dystonia and voice tremorP50DC019900 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Kristina Simonyan · 2021 to 2026
$11.9M
The role of the cerebellum in speechR01DC017091 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John Francis Houde, RICHARD IVRY · 2019 to 2026
$4.5M
Neural mechanisms of speech motor control in Autism Spectrum DisordersR01DC019167 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEMOPOULOS, CARLY, LI, YAN · 2021 to 2025
$4.2M
Electrophysiological and molecular imaging of early AD progressionR01AG088398 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kamalini Gayathree Ranasinghe · 2024 to 2026
$2.4M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaRF1NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA, HOUDE, JOHN FRANCIS · 2023 to 2023
$2.4M
Imaging sensorimotor adaptation and compensation of speechR01DC013979 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOUDE, JOHN FRANCIS, NAGARAJAN, SRIKANTAN S. · 2014 to 2018
$1.7M
Phenotyping the neural basis of sensorimotor control of speech in 16p11.2 deletion syndromeR01DC021711 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Carly Demopoulos, John Francis Houde · 2025 to 2026
$1.4M
Dopamine and sensorimotor function in stutteringR21DC021557 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOUDE, JOHN FRANCIS, MAX, LUDO · 2024 to 2024
$464k
NIA NIH HHS R01 AG088398NIDCD NIH HHS P50 DC019900NIDCD NIH HHS R01 DC013979NIDCD NIH HHS R01 DC017091NIDCD NIH HHS R01 DC019167NIDCD NIH HHS R01 DC021711NIDCD NIH HHS R21 DC021557NINDS NIH HHS RF1 NS100440
6 · The paper itself

Abstract

introductionCognitive decline in Alzheimer's disease (AD) may arise not only from neuronal loss but also from disrupted temporal coordination across distributed networks. Prior works in healthy individuals has shown memory-related modulation of hippocampal-cortical phase-amplitude coupling (PAC). We hypothesized alteration of resting-state hippocampo-cortical PAC in AD which relates to cognitive impairment.

methodsResting-state magnetoencephalography (MEG) data were obtained from 78 AD patients and 70 healthy controls. Source-reconstructed hippocampal and cortical signals were analysed using antisymmetrized bispectral methods to quantify non-linear across-site PAC.

resultsAD patients showed significant disruptions of hippocampo-cortical PAC, particularly involving frontal, parahippocampal, and posterior-cingulate cortices. PAC measures were significantly associated with Mini-Mental State Examination scores within the AD group, with higher PAC corresponding to greater cognitive impairment in regions showing increased coupling relative to controls. DISCUSSION: These findings demonstrate altered hippocampo-cortical temporal coordination in AD and suggest PAC as a potential electrophysiological marker of disease-related network dysfunction.

Indexed as

Alzheimer’s diseasedeep brain activityhippocampusphase-amplitude couplingresting-state magnetoencephalography

Identifiers

PMID41728324
PMCPMC12919100

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.