Evidence map›Paper›PMID 41728300›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Wild-type

Stanislav Tsitkov, Akshay Raju, Jie Wu, Jonathan Li, Ryan G Lim, Zhuoxing Wu, Noura Al Bistami, Answer Als Consortium, Jennifer E Van Eyk, Clive N Svendsen and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Stanislav TsitkovDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Akshay RajuDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jie WuDepartment of Neurobiology and Behavior, University of California, Irvine, CA, USA.
Jonathan LiDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ryan G LimInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.
Zhuoxing WuDepartment of Neurobiology and Behavior, University of California, Irvine, CA, USA.
Noura Al BistamiCenter for Systems and Therapeutics, Gladstone Institutes, University of California, San Francisco, San Francisco, CA, USA.
Answer Als ConsortiumDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jennifer E Van EykAdvanced Clinical Biosystems Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Clive N SvendsenThe Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jeffrey D RothsteinBrain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jonathan D GlassDepartment of Neurology, Emory University, Atlanta, GA, USA.
Steve FinkbeinerCenter for Systems and Therapeutics, Gladstone Institutes, University of California, San Francisco, San Francisco, CA, USA.
Julia A KayeCenter for Systems and Therapeutics, Gladstone Institutes, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-7442-0882
Leslie M ThompsonDepartment of Neurobiology and Behavior, University of California, Irvine, CA, USA.
Ernest FraenkelDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Funding

Genetic characterization of atypical parkinsonismZIANS003154 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SCHOLZ, SONJA · 2016 to 2025
$15.4M
Genome sequencing of Lewy Body Dementia and Frontotemporal Dementia: a public resource for the study of Alzheimers disease and related dementiasZIAAG000935 · NIA · NATIONAL INSTITUTE ON AGING · PI TRAYNOR, BRYAN · 2017 to 2025
$771k
Intramural NIH HHS ZIA AG000935Intramural NIH HHS ZIA NS003154
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is highly heritable, yet the vast majority of cases lack an identifiable genetic cause and clinical progression remains largely unpredictable. To connect noncoding and rare genetic variation to disease phenotypes in a relevant cell type, we generated a multi-omic quantitative trait locus (QTL) atlas from 594 induced-pluripotent-stem-cell-derived human motor neuron lines (522 ALS patients, 72 controls). By mapping cis-QTLs for chromatin accessibility, splicing and gene expression from whole-genome sequencing, we identify common and rare variants on the wild-type

Identifiers

PMID41728300
PMCPMC12919128

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.