Evidence map›Paper›PMID 41728293›Full record

ArticlemedRxiv : the preprint server for health sciences2026

The prognostic value of blood-based p-tau217 levels on progression to clinical impairment.

Rachel F Buckley, Diana L Townsend, Colin J Birkenbihl, Madison Cuppels, Gillian T Coughlan, Mabel T Seto, Jane A Brown, Michael J Properzi, Merle C Hönig, Annie Li and 27 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

37 authors.

Rachel F BuckleyDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Diana L TownsendDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Colin J BirkenbihlDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Madison CuppelsDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Gillian T CoughlanDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Mabel T SetoDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Jane A BrownDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Michael J ProperziDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Merle C HönigDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Annie LiDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Aaron P SchultzDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Jasmeer ChhatwalDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Hyun-Sik YangDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Steven ArnoldDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Pia KivisäkkDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Bryan D JamesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Sid O'BryantUniversity of North Texas Health Science Center, Denton, TX, USA.
Robert A RissmanUniversity of Southern California, Los Angeles, CA, USA.
Melissa PetersenUniversity of North Texas Health Science Center, Fort Worth, TX, USA.
Jessica Z K CaldwellUniversity of Wisconsin-Madison, Madison, WI, USA.
Tobey BetthauserUniversity of Wisconsin-Madison, Madison, WI, USA.
Julie Elisabeth OomensUniversity of Wisconsin-Madison, Madison, WI, USA.
Maria CarriganDepartment of Neurology, Amsterdam UMC, Amsterdam, Netherlands.
Brian HealyDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Jorge Garcia CondadoDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Sterling JohnsonUniversity of Wisconsin-Madison, Madison, WI, USA.
Wai-Ying Wendy YauDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Oliver LangfordUniversity of Southern California, Los Angeles, CA, USA.
Michelle FarrellDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Rebecca E AmariglioDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Dorene M RentzDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Kathryn V PappDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Timothy J HohmanVanderbilt University Medical Center, Nashville, TN, USA.
Michael DonohueUniversity of Southern California, Los Angeles, CA, USA.
Paul S AisenUniversity of Southern California, Los Angeles, CA, USA.
Keith A JohnsonDepartment of Radiology, Mass General Brigham, Boston, MA, USA.
Reisa A SperlingDepartment of Neurology, Mass General Brigham, Boston, MA, USA.

Funding

The Health & Aging Brain Study - Health Disparities (HABS-HD)U19AG078109 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Sid E O'Bryant · 2022 to 2026
$181.1M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
RECRUITMENT COREU19AG010483 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDMAN, HOWARD · 2013 to 2020
$80.6M
Vascular factors, physical activity, and inflammation as modulators of neurodegenerative and cognitive trajectories (Project 2)P01AG036694 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI REISA A. SPERLING · 2010 to 2026
$50.2M
Health and Aging Brain among Latino Elders (HABLE-AT(N)) StudyR01AG058533 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JOHNSON, LEIGH A, O'BRYANT, SID E · 2020 to 2025
$45.4M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Sudeshna Das · 2019 to 2026
$36.5M
Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sanjay Asthana · 2019 to 2026
$34.5M
Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) Open-Label Extension StudyR01AG063689 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI AISEN, PAUL S., SPERLING, REISA A. · 2019 to 2024
$30.8M
The Longitudinal Course of Neural Function and Amyloid in People At Risk for ADR01AG021155 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sterling C Johnson · 2004 to 2026
$27.0M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Health Disparities in Alzheimer's Disease and Mild Cognitive Impairment among Mexican AmericansR01AG054073 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI O'BRYANT, SID E, TOGA, ARTHUR W · 2017 to 2021
$12.6M
NCRR NIH HHS S10 RR021110NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NIA NIH HHS DP2 AG082342NIA NIH HHS P01 AG036694NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062715NIA NIH HHS R01 AG021155NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG054073NIA NIH HHS R01 AG058533NIA NIH HHS R01 AG063689NIA NIH HHS R01 AG070862NIA NIH HHS R01 AG079142NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG010483NIA NIH HHS U19 AG078109NIBIB NIH HHS P41 EB015896NIBIB NIH HHS P41 EB015922
6 · The paper itself

Abstract

Plasma p-tau217 closely tracks amyloid-β (Aβ) pathology, yet its ability to predict long-term clinical progression in cognitively unimpaired (CU) adults remains uncertain. We analyzed harmonized data from 2,705 CU participants (Age

Identifiers

PMID41728293
PMCPMC12919127

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