Evidence map›Paper›PMID 41728292›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Acellular Adipose Tissue promotes anti-fibrotic remodeling in Phase II Study.

Alexis N Peña, Jordan A Garcia, Amy E Anderson, Joel C Sunshine, Carisa M Cooney, Pathik Aravind, Joseph Puthumana, Alexander T F Bell, Elana J Fertig, Patrick Byrne and 2 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexis N PeñaTranslational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-1899-8625
Jordan A GarciaTranslational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-3336-0294
Amy E AndersonTranslational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Joel C SunshineDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-9987-6712
Carisa M CooneyDepartment of Plastic and Reconstructive Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-5475-206X
Pathik AravindDepartment of Plastic and Reconstructive Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8308-3125
Joseph PuthumanaDepartment of Plastic and Reconstructive Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Alexander T F BellDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD USA.ORCID 0000-0002-8388-9954
Elana J FertigDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD USA.ORCID 0000-0003-3204-342X
Patrick ByrneHead and Neck Institute, Cleveland Clinic, Cleveland, OH, USA.
Damon S CooneyDepartment of Plastic and Reconstructive Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-2786-287X
Jennifer H ElisseeffTranslational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-5066-1996

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6M
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
TR&D Project 3P41EB028239 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Jordan Green, JONATHAN P SCHNECK · 2019 to 2026
$11.5M
RESEARCH TRAINING IN OTOLARYNGOLOGYT32DC000027 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI CAREY, JOHN PATRICK · 1989 to 2023
$5.5M
NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA047904NIBIB NIH HHS P41 EB028239NIDCD NIH HHS T32 DC000027
6 · The paper itself

Abstract

Acellular Adipose Tissue (AAT) is an off-the-shelf, cadaveric adipose-derived ECM-based biomaterial for soft tissue reconstruction. AAT has been validated preclinically to promote angiogenesis and adipogenesis and demonstrated safety, biocompatibility, and tolerability in a Phase I study. In this study we report the findings for the first ten patients in the Phase II study for permanent reconstruction of modest soft tissue defects. AAT promoted macrophages, CD3

Indexed as

adipose tissue productbiomaterialsmultiplex immunofluorescence stainingsoft tissue reconstructionspatial transcriptomicsvolume correction

Identifiers

PMID41728292
PMCPMC12919111

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.