Mexiletine prevents transient heart failure in a polymicrogyria child with an ATP1A3 variant: a case report.

Mai Aida, Junichi Ozawa, Yuya Takahashi, Satoko Miyatake, Kenichi Watanabe

Abstract readCase Reports

In one paragraph

Article in European heart journal. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mai AidaDepartment of Pediatrics, Nagaoka Red Cross Hospital, 2-297-1, Senshu, Nagaoka, Niigata 940-2085, Japan.ORCID https://orcid.org/0009-0002-9592-8997

Junichi OzawaDepartment of Pediatrics, Nagaoka Red Cross Hospital, 2-297-1, Senshu, Nagaoka, Niigata 940-2085, Japan.ORCID https://orcid.org/0000-0002-6149-2649

Yuya TakahashiDepartment of Pediatrics, Nagaoka Red Cross Hospital, 2-297-1, Senshu, Nagaoka, Niigata 940-2085, Japan.ORCID https://orcid.org/0009-0008-9142-5069

Satoko MiyatakeDepartment of Human Genetics, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.ORCID https://orcid.org/0000-0001-7587-5168

Kenichi WatanabeDepartment of Pediatrics, Nagaoka Red Cross Hospital, 2-297-1, Senshu, Nagaoka, Niigata 940-2085, Japan.ORCID https://orcid.org/0000-0002-1413-729X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Several variants in Case summary: The patient was a 5-year-old female who suffered from intractable seizures since birth and was diagnosed with polymicrogyria based on a head magnetic resonance imaging scan. Whole-exome sequencing identified a Discussion: Loss of function of the Na-K-ATPase caused high concentrations of intracellular Na

Indexed as

ATP1A3Case reportHeart failureMexiletineNa+/K+ ATPasePolymicrogyria

Identifiers

PMID41728224

DOI10.1093/ehjcr/ytag106

PMCPMC12924159

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.