ArticleFrontiers in cellular and infection microbiology2026
Neutrophil-to-lymphocyte ratios as easy-to-use biomarkers for the diagnosis of active tuberculosis in children and adolescents.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The diagnosis of active tuberculosis (ATB) in children and adolescents is limited by non-specific symptoms, paucibacillary infection, and the low sensitivity of traditional tools. These limitations can lead to delayed treatment and increased complications. Methods: This retrospective study recruited 1,080 participants. We performed receiver operating characteristic (ROC) curves to evaluate the diagnostic performance of logarithmic neutrophil-to-lymphocyte ratio (logNLR) for ATB infection. We employed logistic regression, restricted cubic spline (RCS), stratified, and interaction analyses to evaluate the association between logNLR and ATB infection. Results: The logNLR was significantly associated with ATB infection in the adjusted model (OR = 1.38, 95% CI: 1.01-1.88, P = 0.044). The RCS curve indicated a non-linear relationship between logNLR and ATB infection, with the critical threshold of 0.9232. The breakpoint analyses further confirmed that when logNLR<1.379, the indicator logNLR was positively correlated with ATB infection. Stratified analyses showed logNLR was a reliable predictor in males, 0-7 and 15-17 years old, those with Conclusions: The logNLR is a simple, low-cost, and effective biomarker for diagnosis of ATB in children and adolescents. The critical threshold and breakpoint of logNLR enable precise risk stratification, providing valuable support for early ATB identification in this population.
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