Evidence map›Paper›PMID 41728041›Full record

ArticleJournal of extracellular biology2026

Extracellular Vesicle Properties and Functions Are Defined by the Originating Cell's Fitness Status.

Stephanie Leyk, Imke Liebold, Clarissa Lanzloth, Ulricke Richardt, Johan M Kux, Christoph Kilian, Manuela Moritz, Antonia Gocke, Simon Meyer, Katharina Höhn and 12 more

Abstract read
In one paragraph

Article in Journal of extracellular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Stephanie LeykI. Department of Medicine University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.
Imke LieboldI. Department of Medicine University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.
Clarissa LanzlothI. Department of Medicine University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.
Ulricke RichardtProtozoa Immunology Bernhard-Nocht-Institute for Tropical Medicine (BNITM) Hamburg Germany.
Johan M KuxCell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.
Christoph KilianI. Department of Medicine University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.
Manuela MoritzSection/Core Facility Mass Spectrometry and Proteomics, Center for Diagnostics University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.
Antonia GockeSection/Core Facility Mass Spectrometry and Proteomics, Center for Diagnostics University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.
Simon MeyerI. Department of Medicine University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.
Katharina HöhnCellular Parasitology Department Bernhard-Nocht-Institute for Tropical Medicine (BNITM) Hamburg Germany.
Barbara HoneckerMolecular Infection Immunology Bernhard-Nocht-Institute for Tropical Medicine (BNITM) Hamburg Germany.
Helmut HaashelminGuard Sülfeld/Borstel Germany.
Marius BöttcherI. Department of Medicine University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.
Sören WeidemannInstitute of Pathology with the sections Molecular Pathology and Cytopathology University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.
Simon KindInstitute of Pathology with the sections Molecular Pathology and Cytopathology University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.
Hartmut SchlüterSection/Core Facility Mass Spectrometry and Proteomics, Center for Diagnostics University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.
Nahla Galal MetwallyResearch Group Host-Parasite Interaction Bernhard-Nocht-Institute for Tropical Medicine (BNITM) Hamburg Germany.
Lorenz AdlungI. Department of Medicine University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.
Pablo J SáezCell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.
Thomas JacobsProtozoa Immunology Bernhard-Nocht-Institute for Tropical Medicine (BNITM) Hamburg Germany.
Klaus RuckdeschelInstitute of Medical Microbiology, Virology and Hygiene University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.
Lidia BosurgiI. Department of Medicine University Medical Center Hamburg-Eppendorf (UKE) Hamburg Germany.ORCID https://orcid.org/0000-0002-8775-4950

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have focused on the role of dying cells in modulating immune function and shaping the local microenvironment. Apoptotic cells release various extracellular vesicles (EVs), such as exosomes and microvesicles, and form apoptotic bodies through membrane blebbing. Despite growing interest in EVs, the effects of EVs derived from apoptotic cells versus those from live cell remain poorly understood. Here, via transmission electron microscopy, nanoparticle tracking analysis, proteomics, and flow cytometry, we characterise the distinct features of EVs from live versus apoptotic cells. Using a model of

Indexed as

apoptosisapoptotic bodiesextracellular vesiclesmacrophagesschistosomiasis

Identifiers

PMID41728041
PMCPMC12918768

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.