Evidence map›Paper›PMID 41727965›Full record

ArticleJournal of translational internal medicine2026

PFKP binding AMOTL1 promotes tumor aerobic glycolysis and epithelial-mesenchymal transition by modulating Hippo pathway in head and neck cancer.

Lingwa Wang, Haiyang Li, Yifan Yang, Qian Shi, Ling Feng, Ru Wang, Jugao Fang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lingwa WangDepartment of Otorhinolaryngology Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University; Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Institute of Otorhinolaryngology, Beijing, China.
Haiyang LiDepartment of Otorhinolaryngology Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University; Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Institute of Otorhinolaryngology, Beijing, China.
Yifan YangDepartment of Otorhinolaryngology Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University; Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Institute of Otorhinolaryngology, Beijing, China.
Qian ShiDepartment of Otorhinolaryngology Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University; Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Institute of Otorhinolaryngology, Beijing, China.
Ling FengDepartment of Otorhinolaryngology Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University; Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Institute of Otorhinolaryngology, Beijing, China.
Ru WangDepartment of Otorhinolaryngology Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University; Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Institute of Otorhinolaryngology, Beijing, China.ORCID https://orcid.org/0000-0003-0143-5383
Jugao FangDepartment of Otorhinolaryngology Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University; Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Institute of Otorhinolaryngology, Beijing, China.ORCID https://orcid.org/0000-0002-0188-7120

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Aerobic glycolysis drives cancer progression through phosphofructokinase (PFK)-mediated regulation. The contribution of platelet-type PFK (PFKP) to head and neck squamous cell carcinoma (HNSCC) pathogenesis remains undefined. Methods: Bioinformatic screening of 548 TCGA-HNSCC cases identified glycolysis-related prognostic genes Results: PFKP emerged as the pivotal prognostic biomarker for HNSCC, demonstrating significant upregulation at mRNA/protein levels in tumors versus normal tissues (TCGA/clinical cohorts) and correlating with reduced overall and disease-specific survival. Conclusions: PFKP remodels tumor metabolism and drives EMT in HNSCC

Indexed as

aerobic glycolysishead and neck cancerphosphofructokinase platelet

Identifiers

PMID41727965
PMCPMC12916276

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.