Evidence map›Paper›PMID 41727925›Full record

ReviewO&G open2026

The Route of Misoprostol in Reducing Blood Loss for Transperitoneal Myomectomies: A Systematic Review and Meta-analysis.

Nadi Kaonga, Emma Patterson, Mariana C Sanchez-Medina, Tionne Pete, Natalie Rilo, Erin Reardon, Scott Eugley, Cara Frankenfeld, Toby Fitzgerald

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in O&G open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nadi KaongaDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia; Tufts University School of Medicine, MaineHealth Medical Center, Portland, Maine; Department of Obstetrics and Gynecology, Kaiser Oakland, Oakland, California; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, Georgia; Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado; Woodruff Health Sciences Center Library, Emory University, Atlanta, Georgia; and Center for Interdisciplinary Population & Health Research and Department of Obstetrics and Gynecology, MaineHealth, Portland, Maine.
Emma PattersonDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia; Tufts University School of Medicine, MaineHealth Medical Center, Portland, Maine; Department of Obstetrics and Gynecology, Kaiser Oakland, Oakland, California; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, Georgia; Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado; Woodruff Health Sciences Center Library, Emory University, Atlanta, Georgia; and Center for Interdisciplinary Population & Health Research and Department of Obstetrics and Gynecology, MaineHealth, Portland, Maine.
Mariana C Sanchez-MedinaDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia; Tufts University School of Medicine, MaineHealth Medical Center, Portland, Maine; Department of Obstetrics and Gynecology, Kaiser Oakland, Oakland, California; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, Georgia; Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado; Woodruff Health Sciences Center Library, Emory University, Atlanta, Georgia; and Center for Interdisciplinary Population & Health Research and Department of Obstetrics and Gynecology, MaineHealth, Portland, Maine.
Tionne PeteDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia; Tufts University School of Medicine, MaineHealth Medical Center, Portland, Maine; Department of Obstetrics and Gynecology, Kaiser Oakland, Oakland, California; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, Georgia; Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado; Woodruff Health Sciences Center Library, Emory University, Atlanta, Georgia; and Center for Interdisciplinary Population & Health Research and Department of Obstetrics and Gynecology, MaineHealth, Portland, Maine.
Natalie RiloDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia; Tufts University School of Medicine, MaineHealth Medical Center, Portland, Maine; Department of Obstetrics and Gynecology, Kaiser Oakland, Oakland, California; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, Georgia; Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado; Woodruff Health Sciences Center Library, Emory University, Atlanta, Georgia; and Center for Interdisciplinary Population & Health Research and Department of Obstetrics and Gynecology, MaineHealth, Portland, Maine.
Erin ReardonDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia; Tufts University School of Medicine, MaineHealth Medical Center, Portland, Maine; Department of Obstetrics and Gynecology, Kaiser Oakland, Oakland, California; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, Georgia; Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado; Woodruff Health Sciences Center Library, Emory University, Atlanta, Georgia; and Center for Interdisciplinary Population & Health Research and Department of Obstetrics and Gynecology, MaineHealth, Portland, Maine.
Scott EugleyDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia; Tufts University School of Medicine, MaineHealth Medical Center, Portland, Maine; Department of Obstetrics and Gynecology, Kaiser Oakland, Oakland, California; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, Georgia; Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado; Woodruff Health Sciences Center Library, Emory University, Atlanta, Georgia; and Center for Interdisciplinary Population & Health Research and Department of Obstetrics and Gynecology, MaineHealth, Portland, Maine.
Cara FrankenfeldDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia; Tufts University School of Medicine, MaineHealth Medical Center, Portland, Maine; Department of Obstetrics and Gynecology, Kaiser Oakland, Oakland, California; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, Georgia; Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado; Woodruff Health Sciences Center Library, Emory University, Atlanta, Georgia; and Center for Interdisciplinary Population & Health Research and Department of Obstetrics and Gynecology, MaineHealth, Portland, Maine.
Toby FitzgeraldDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia; Tufts University School of Medicine, MaineHealth Medical Center, Portland, Maine; Department of Obstetrics and Gynecology, Kaiser Oakland, Oakland, California; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, Georgia; Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado; Woodruff Health Sciences Center Library, Emory University, Atlanta, Georgia; and Center for Interdisciplinary Population & Health Research and Department of Obstetrics and Gynecology, MaineHealth, Portland, Maine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the efficacy of different routes of misoprostol administration (sublingual, vaginal, rectal) in reducing intraoperative blood loss, which remains a concern for the surgical management of uterine leiomyomas. DATA SOURCES: The protocol was registered in PROSPERO (CRD42025637576). Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analysis) guidelines, we searched several databases (Ovid Medline, Embase, Scopus, Web of Science, Cochrane, Global Health, Global Index Medicus, ClinicalTrials.gov) through June 2024. METHODS OF STUDY SELECTION: The references were screened and data were abstracted in Covidence for studies meeting inclusion criteria. Title abstract screening was conducted, followed by full-text review and then data abstraction. Analyses were conducted with R. TABULATION INTEGRATION AND

resultsThere were 328 studies identified in the initial search. Of those, 26 studies were included for analysis, but only 20 were able to undergo network meta-analysis against the primary outcome of interest (blood loss). Rectal misoprostol administration was associated with the largest mean reduction in intraoperative blood loss (mean difference -152.43 mL, 95% CI, -228.43 to -76.44,

conclusionRoute of misoprostol administration does matter in reducing blood loss during abdominal myomectomy with rectal administration favored, although the data are limited for sublingual administration. SYSTEMATIC REVIEW REGISTRATION: PROSPERO, CRD42025637576.

Identifiers

PMID41727925
PMCPMC12922920

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.