ArticleCureus2026
From Pulmonary Tuberculosis to Antineutrophil Cytoplasmic Antibody (ANCA) Seroconversion: A Case of Rapidly Progressive Glomerulonephritis.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a small-vessel inflammatory disorder that can lead to rapidly progressive glomerulonephritis. Although tuberculosis has been linked to ANCA positivity, the development of biopsy-confirmed immune-mediated kidney disease during anti-tuberculosis therapy is rare. Herein, we describe a rare presentation of delayed ANCA seroconversion associated with rapidly progressive glomerulonephritis in a patient undergoing pulmonary tuberculosis treatment. We report the clinical course, laboratory findings, histopathology, and management of the case. A 49-year-old man with pulmonary tuberculosis initially presented with mild renal impairment and negative autoimmune serology and was treated with standard anti-tuberculosis therapy. Several months later, he developed recurrent hemoptysis accompanied by rapidly worsening kidney function and active urinary sediment. Repeat serological evaluation demonstrated a new cytoplasmic staining pattern on indirect immunofluorescence for antineutrophil cytoplasmic antibodies, consistent with proteinase 3 antibody positivity on antigen-specific immunoassay. Renal biopsy revealed pauci-immune crescentic glomerulonephritis, confirming ANCA-associated rapidly progressive glomerulonephritis. Following a multidisciplinary discussion, immunosuppressive therapy was initiated, and anti-tuberculosis treatment was continued. Despite the therapy, the patient remained dialysis dependent. In summary, delayed ANCA seroconversion may occur during anti-tuberculosis therapy and may be associated with severe immune-mediated renal disease. Kidney biopsy is essential when unexplained kidney deterioration develops during treatment. In selected patients with severe organ involvement, immunosuppressive therapy may be required despite active infection, following careful multidisciplinary evaluation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.