ReviewFrontiers in pediatrics2026
Risk factors of necrotizing enterocolitis in very low birth weight infants: a meta-analysis.
Review in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
Funding
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Abstract
Background: This study aims to explore the primary risk factors for necrotizing enterocolitis (NEC) in very low birth weight (VLBW) infants through meta-analysis, providing scientific evidence for clinical prevention and treatment. Methods: A systematic search was conducted in PubMed, Embase, Cochrane Library, and Web of Science databases for studies investigating risk factors for NEC in VLBW infants, covering the period from database inception to October 10, 2025. Eligible studies included case-control studies, cohort studies, and cross-sectional studies meeting the inclusion criteria. Quality assessment was performed using the NOS and AHRQ scores. Data were pooled using Stata 15 software with a random-effects model. Results: a total of 16 research articles involving 179,289 patients included, meta-analysis results suggest that Small Gestational Age [OR = 1.35, 95% CI (1.14, 1.60)], red blood cells transfusion [OR = 1.75, 95% CI (1.26, 2.43)], maternal hypertensive disorders [OR = 1.27, 95% CI (1.03, 1.57)], patent ductus arteriosus [OR = 1.56, 95% CI (1.30, 1.88)], sepsis [OR = 1.87, 95% CI (1.22, 2.87)] were associated with NEC in very low birth weight infants. Conclusion: This systematic meta-analysis consolidates and confirms previously reported associations between several clinical factors and the risk of necrotizing enterocolitis in very low birth weight infants. The findings support the association of small gestational age, red blood cell transfusion, maternal hypertensive disorders, patent ductus arteriosus, and sepsis with an increased risk of NEC. Systematic Review Registration: PROSPERO CRD420251149565.
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