Evidence map›Paper›PMID 41727733›Full record

ArticleAdvanced functional materials2025

Anionic Citrate-Based 3D-Printed Scaffolds for Tunable and Sustained Orthobiologic Delivery to Enhance Tissue Regeneration.

Se-Hwan Lee, Ruqiang Lu, Andrew House, Zizhao Li, Lindsey Hammond Burton, Katie Josephine Sikes, Lynn Marie Pezzanite, Drew William Koch, Kevin Michael Labus, Ben Gadomski and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Se-Hwan LeeMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, 3450 Hamilton Walk, Philadelphia, PA 19104, USA.
Ruqiang LuAcuitive Technologies, Inc., 50 Commerce Drive, Allendale, NJ 07401, USA.
Andrew HouseAcuitive Technologies, Inc., 50 Commerce Drive, Allendale, NJ 07401, USA.
Zizhao LiDepartment of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, PA 19104, USA.
Lindsey Hammond BurtonPreclinical Surgical Research Laboratory, Translational Medicine Institute, Colorado State University, 2350 Gillette Drive, Fort Collins, CO 80523, USA.
Katie Josephine SikesPreclinical Surgical Research Laboratory, Translational Medicine Institute, Colorado State University, 2350 Gillette Drive, Fort Collins, CO 80523, USA.
Lynn Marie PezzanitePreclinical Surgical Research Laboratory, Translational Medicine Institute, Colorado State University, 2350 Gillette Drive, Fort Collins, CO 80523, USA.
Drew William KochPreclinical Surgical Research Laboratory, Translational Medicine Institute, Colorado State University, 2350 Gillette Drive, Fort Collins, CO 80523, USA.
Kevin Michael LabusOrthopedic Bioengineering Research Laboratory, Translational Medicine Institute, Colorado State University, 2350 Gillette Drive, Fort Collins, CO 80523, USA.
Ben GadomskiOrthopedic Bioengineering Research Laboratory, Translational Medicine Institute, Colorado State University, 2350 Gillette Drive, Fort Collins, CO 80523, USA.
Jeremiah EasleyPreclinical Surgical Research Laboratory, Translational Medicine Institute, Colorado State University, 2350 Gillette Drive, Fort Collins, CO 80523, USA.
Richard Tuan TranAcuitive Technologies, Inc., 50 Commerce Drive, Allendale, NJ 07401, USA.
Su Chin HeoMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, 3450 Hamilton Walk, Philadelphia, PA 19104, USA.

Funding

Dynamic Fibrous Scaffolds for Repairing Dense Connective TissuesR01AR056624 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Jason A Burdick, Robert L Mauck · 2009 to 2026
$7.5M
Biophysical regulation of genome architecture in meniscus cellsK01AR077087 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI HEO, SU CHIN · 2020 to 2024
$632k
NIAMS NIH HHS K01 AR077087NIAMS NIH HHS R01 AR056624
6 · The paper itself

Abstract

Sustained and controlled release systems for orthobiologics enhance therapeutic efficacy by enabling precise biomolecule delivery. While bone morphogenetic protein-2 (BMP-2) in combination with bone grafts has shown promise in orthopedic applications, adverse effects related to the burst release of supraphysiological doses limit its clinical utility. To address this challenge, a novel anionic citrate-based 3D-printed scaffold was developed designed to sequester and localize orthobiologic activity at the target site, allowing effective delivery at significantly lower concentrations. Composed of an anionic citrate-based polymer and

Indexed as

3D printed scaffoldanionic citrate-based polymercontrolled releaseorthobiologicsequestration

Identifiers

PMID41727733
PMCPMC12923088

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.