ArticleFrontiers in endocrinology2026
Development and validation of a clinical nomogram for predicting cumulative live birth rate in ovarian endometrioma patients undergoing ethanol sclerotherapy and
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Effective individualized tools to predict cumulative live birth rates are lacking for patients with ovarian endometriomas undergoing Methods: This retrospective study analyzed the clinical data of 194 patients with ovarian endometriosis who underwent ethanol sclerotherapy followed by Results: A total of 194 patients were included, with an overall cumulative live birth rate of 50.0% (97/194). Multivariate regression analysis identified four independent predictors of the cumulative live birth rate: previous live birth history, controlled ovarian hyperstimulation protocol, number of oocytes retrieved, and cyst diameter. The nomogram constructed using these variables exhibited good discriminatory ability in both the training and validation cohorts, with areas under the curve of 0.849 (95% Confidence Interval: 0.782-0.912) and 0.853 (95% Confidence Interval: 0.754-0.952), respectively. Bootstrap validation (500 iterations) confirmed the stability of the model. Calibration was acceptable (Hosmer-Lemeshow test, P>0.05), and decision curve analysis indicated a favorable net benefit across a threshold probability range of 10-50%, demonstrating its clinical utility. Conclusions: This study developed and validated a parsimonious nomogram model that accurately predicts the cumulative live birth rate in patients with ovarian endometriosis undergoing
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