Evidence map›Paper›PMID 41727691›Full record

ArticleFrontiers in endocrinology2026

Effect of acupuncture pretreatment on clinical pregnancy rate in women with diminished ovarian reserve undergoing IVF-ET: study protocol for a multicenter randomized controlled trial.

Xin Liu, Chenchen Su, Junmin Li, Li Chen, Qinhua Zhang, Yan Sun, Jinbang Xu, Cuilian Zhang, Xinjie Cheng, Xuemei Li and 20 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Xin LiuThe Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Chenchen SuThe Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Junmin LiReproductive Medicine Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Li ChenReproductive Medicine Center, General Hospital of Eastern Theater Command, Nanjing, China.
Qinhua ZhangReproductive Medicine Center, Shanghai University of Traditional Chinese Medicine Affiliated Shuguang Hospital, Shanghai, China.
Yan SunReproductive Medicine Center, Fujian Maternal and Child Health Hospital, Fuzhou, China.
Jinbang XuDepartment of Traditional Chinese Medicine, Fujian Maternal and Child Health Hospital, Fuzhou, China.
Cuilian ZhangReproductive Medicine Center, Henan Provincial People's Hospital, Zhengzhou, China.
Xinjie ChengDepartment of Rehabilitation Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
Xuemei LiReproductive Medicine Center, Shenzhen Maternal and Child Health Hospital, Shenzhen, China.
Huisheng YangDepartment of Acupuncture and moxibustion Massage, Shenzhen Maternal and Child Health Hospital, Shenzhen, China.
Yicong XieDepartment of Traditional Chinese Medicine, Tianjin Medical University General Hospital, Tianjin, China.
Jie YangAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Na ZhuReproductive Medicine Center, Reproductive and Genetic Hospital of China International Trust and Investment Corporation (CITIC)-Xiangya, Changsha, China.
Weiying LuReproductive Medicine Center, Hainan Women and Children's Medical Center, Haikou, China.
Tongsheng SuDepartment of Acupuncture, Shaanxi Provincial Hospital of Chinese Medicine, Xian, China.
Wei ShangReproductive Medicine Center, The Seventh Medical Center of the Chinese PLA General Hospital, Beijing, China.
Qun LuReproductive Medicine Center, Beijing Chaoyang Hospital of Capital Medical University, Beijing, China.
Li YangThe Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Jiashan LiThe Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Tian HangThe Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Lingyu QiThe Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Qiwei XiaoThe Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Weixin LiThe Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Feng GaoThe Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Xiaoyan WangThe Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Pengfei DuThe Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Dongxue AnThe Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Huanfang XuThe Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Yigong FangThe Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Diminished ovarian reserve (DOR) is known to reduce the likelihood of achieving pregnancy or live births in women undergoing Methods and analysis: This study is a multicenter, randomized, placebo-controlled trial conducted on a large scale. A total of 300 women with DOR preparing for IVF-ET will be randomized 1:1 to acupuncture or placebo acupuncture. Interventions will be administered from the second menstrual cycle preceding the IVF cycle until the day of oocyte retrieval. The primary outcome is the clinical pregnancy rate (CPR) following the first embryo transfer. Secondary outcomes include various IVF-ET indicators, such as the number of follicles ≥ 14 mm, estradiol (E2) levels, and endometrial thickness on the day of human chorionic gonadotropin (hCG) administration; the number of retrieved oocytes, metaphase II (MII) oocytes, and two pronuclei (2PN) fertilizations; as well as the rates of 2PN fertilization, available embryos, high-quality embryos, implantation, cycle cancellation, biochemical pregnancy, pregnancy loss, sustained pregnancy, and live birth. Additionally, ovarian reserve indicators-including antral follicle count (AFC), basal serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and E2, and anti-Müllerian hormone (AMH)-along with scores from the Self-Rating Anxiety Scale (SAS) will also be evaluated. Ethics and dissemination: The trial has been approved by the ethics committees of all participating centers. The results will be disseminated in academic journals. Clinical Trial Registration: http://itmctr.ccebtcm.org.cn/, identifier ID: ITMCTR2024000021.

Indexed as

Acupuncture TherapyEmbryo TransferFertilization in VitroInfertility, FemaleOvarian ReservePregnancy RateAdultFemaleHumansMulticenter Studies as TopicOvulation InductionPregnancyRandomized Controlled Trials as Topicacupunctureclinical pregnancy ratediminished ovarian reservein vitrofertilization-embryo transfermulti-centerrandomized controlled trialstudy protocol

Identifiers

PMID41727691
PMCPMC12917761

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.