ReviewFrontiers in oncology2026
Macrophage-based therapeutic strategies in glioblastoma: advancements in drug delivery and immunotherapy.
Review in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Local Nanomedicine and Nano-Enabled Biomaterials After Glioblastoma Resection.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioblastoma (GBM) is a highly aggressive brain tumor, characterized by extensive infiltration, neovascularization, and resistance to conventional therapies. The unique tumor microenvironment (TME) of GBM is shaped by the blood-brain barrier (BBB), immune cells, and glioma-derived factors, complicating treatment efficacy. Macrophages, particularly tumor-associated macrophages (TAMs), play critical roles in GBM progression through immune evasion, angiogenesis, and therapeutic resistance. Advances in macrophage-based therapies, including engineered macrophages (CAR-M) and macrophage-mimetic nanoplatforms, offer promising strategies for targeted treatment. These approaches leverage macrophages' natural ability to cross the BBB and selectively accumulate in tumors, enhancing therapeutic outcomes. This review highlights the roles of macrophages in the GBM TME, recent developments in macrophage-based drug delivery systems, and the potential of CAR-M therapies for improving GBM treatment efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.