ArticleFrontiers in oncology2026
The expression pattern and prognostic relevance of p120-catenin, COL4A2 and SOX10 in glioma.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: p120-catenin, COL4A2 and SOX10 are emerging as modulators of glioma pathophysiology and progression. This study aimed to characterize the expression pattern of these markers in glioma tissues with different degrees of malignancy, and tested their prognostic value for the outcome of glioblastoma IDH wild-type (GBM IDH Methods: All markers were assessed by immunohistochemistry in tissue microarrays prepared from healthy brain (n=38), astrocytoma grade 2 (n=24), astrocytoma grade 3 (n=22), and GBM IDH Results: The levels of p120-catenin significantly increased with the degree of glioma malignancy (p<0.001; Rho=0.599), while the opposite was observed for COL4A2 (p<0.001, Rho=-0.387) and SOX10 (p<0.001; Rho=-0.293). High levels of p120-catenin significantly associated with and predicted the poor overall survival of GBM IDH Conclusions: p120-catenin is a potential tumor-promoting factor in glioma, and a prognostic marker in GBM. In contrast, COL4A2 and SOX10 appear to act as tumor suppressors in glioma pathophysiology. SOX10 may additionally be a valuable prognostic marker in female GBM patients.
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