Evidence map›Paper›PMID 41727610›Full record

ArticleResearch square2026

Multiplexed single-tier immunoassay for improved Lyme disease diagnosis across all disease stages.

Phillip Stafford, Holly Ahern, John Aucott, Alison Rebman, Elizabeth J Horn, Marianne Hathaway, Madeleine Saunders, Nicole R Hasenkampf, Monica E Embers

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Phillip StaffordArizona State University, School of Life Sciences, Tempe, AZ.ORCID https://orcid.org/0000-0001-7989-9036
Holly AhernState University of New York, Adirondack, Queensbury, NY.ORCID https://orcid.org/0000-0002-6526-6948
John AucottJohns Hopkins University School of Medicine, Baltimore, MD.ORCID https://orcid.org/0000-0002-2648-0896
Alison RebmanJohns Hopkins University School of Medicine, Baltimore, MD.ORCID https://orcid.org/0000-0002-2875-8812
Elizabeth J HornThe Lyme Disease Biobank, Portland, OR.ORCID https://orcid.org/0000-0001-5928-9652
Marianne HathawayTulane National Biomedical Research Center, Covington, LA.
Madeleine SaundersTulane National Biomedical Research Center, Covington, LA.ORCID https://orcid.org/0000-0001-5453-8082
Nicole R HasenkampfTulane National Biomedical Research Center, Covington, LA.ORCID https://orcid.org/0000-0003-2293-8078
Monica E EmbersTulane National Biomedical Research Center, Covington, LA.ORCID https://orcid.org/0000-0003-4051-7592

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
A Multiplex Platform for Lyme Disease Diagnosis and Treatment ResponseR21AI100166 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI EMBERS, MONICA E · 2012 to 2013
$449k
NIAID NIH HHS R21 AI100166NIH HHS P51 OD011104
6 · The paper itself

Abstract

Lyme disease is the most common vector-borne infection in North America and Europe, yet current two-tier serologic testing shows poor sensitivity during early infection when antibiotic treatment is most effective. We developed and validated a single-tier multiplex immunoassay that combines ten

Identifiers

PMID41727610
PMCPMC12919177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.