Evidence map›Paper›PMID 41727605›Full record

ArticleResearch square2026

Dual-Modality Bioactive Repair of Facial Nerve Injury Using PEG-Mediated Axonal Fusion and Extracellular Vesicles-Enriched Human GMSC Secretome.

Justin C Burrell, Qunzhou Zhang, Shi Shihong, Mykhailo M Tatarchuk, David R Clizbe, D Kacy Cullen, Anh D Le

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Justin C BurrellUniversity of Pennsylvania.
Qunzhou ZhangUniversity of Pennsylvania.
Shi ShihongUniversity of Pennsylvania.
Mykhailo M TatarchukUniversity of Pennsylvania.
David R ClizbeUniversity of Pennsylvania.
D Kacy CullenUniversity of Pennsylvania.
Anh D LeUniversity of Pennsylvania.

Funding

Tissue Engineered Nigrostriatal Pathway for Anatomical Tract Reconstruction in Parkinson's DiseaseR01NS127895 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Daniel Kacy Cullen · 2023 to 2026
$2.3M
Tissue Engineered Motor Units for Neuromuscular Modeling and RepairR01AR083489 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Daniel Kacy Cullen · 2024 to 2026
$1.7M
Advanced Training at the Interface of Engineering and Oral-Craniofacial SciencesT90DE030854 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI Hyun Koo, Kathleen J Stebe · 2021 to 2026
$1.4M
BLRD VA I01 BX003748NIAMS NIH HHS R01 AR083489NIDCR NIH HHS T90 DE030854NINDS NIH HHS R01 NS127895
6 · The paper itself

Abstract

Facial nerve injuries may cause severe functional deficits with limited recovery after standard neurorrhaphy. Polyethylene glycol (PEG)-mediated axonal fusion enables immediate structural reconnection and prevents Wallerian degeneration, while gingiva-derived mesenchymal stem cell (GMSC) secretome provides a potent, acellular trophic stimulus that supports neuronal survival and remyelination. We report a dual-modality bioactive repair interface integrating PEG fusion with human GMSC secretome to accelerate neural repair. Fluorescently labeled secretome components were rapidly internalized by neurons

Indexed as

Axonal regenerationFacial nerve repairGingiva mesenchymal stem cellsPeripheral nerve regenerationPolyethylene glycol fusionSecretome therapy

Identifiers

PMID41727605
PMCPMC12919172

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.