Evidence map›Paper›PMID 41727568›Full record

ArticleResearch square2026

Hematopoietic stem cell aging promotes

Marco De Dominici, Lamis Naddaf, Angelica Varesi, Andrew Goodspeed, Bridget Hoag, Vadym Zaberezhnyy, Johannes Menzel, Yang Liu, Stephanie Xie, Sheng Li and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marco De DominiciThe Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Lamis NaddafDepartment of Cancer Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Angelica VaresiDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Andrew GoodspeedBioinformatics and Biostatistics Shared Resource, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Bridget HoagThe Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Vadym ZaberezhnyyThe Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Johannes MenzelThe Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Yang LiuDepartment of Cancer Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Stephanie XiePrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID 0000-0002-0284-494X
Sheng LiDepartment of Cancer Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
James DeGregoriThe Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-1287-1976

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
An Integrative Computational Framework for DNA Hydroxymethylation Data Mining and InterpretationR35GM133562 · NIGMS · JACKSON LABORATORY · PI LI, SHENG · 2019 to 2023
$2.4M
The impact of reduction of cellular senescence on age-related epigenetic heterogeneityU01CA271830 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DEGREGORI, JAMES V, LI, SHENG · 2021 to 2025
$1.9M
Determining how aging-associated changes in the microenvironment contribute to leukemogenesisR01AG067584 · NIA · UNIVERSITY OF COLORADO DENVER · PI DEGREGORI, JAMES V · 2019 to 2022
$1.7M
Aged tissue environments as drivers of oncogenic adaptation in hematopoiesisR01AG066544 · NIA · UNIVERSITY OF COLORADO DENVER · PI DEGREGORI, JAMES V · 2020 to 2024
$1.1M
3D Genome Reorganization and Epigenome Dynamics of Clonal HematopoiesisR56AG071766 · NIA · JACKSON LABORATORY · PI LI, SHENG, OGURO, HIDEYUKI · 2022 to 2022
$343k
NCI NIH HHS P30 CA046934NCI NIH HHS U01 CA271830NIA NIH HHS R01 AG066544NIA NIH HHS R01 AG067584NIA NIH HHS R56 AG071766NIGMS NIH HHS R35 GM133562
6 · The paper itself

Abstract

Aging is strongly associated with the incidence of clonal hematopoiesis (CH) and myeloid malignancies. However, the role of aging in the clonal selection for CH mutations is not well understood. In a mouse model of CH, we observe that transplanted

Identifiers

PMID41727568
PMCPMC12919197

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.