ArticleJournal of pain research2026
Efficacy of Tender Point Infiltrations (TPI) in Patients with Acute and Subacute Zoster-Associated Pain: Study Protocol for a Randomized, Prospective, Multicenter, Blinded Endpoint, Open-Label Controlled Trial.
Article in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk prediction models for postherpetic neuralgia: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- Advancing the Prevention of Postherpetic Neuralgia: Methodological and Clinical Considerations for the TPI Study Protocol [Letter].Journal of pain research · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Herpes zoster (HZ) can adversely influence patients' quality of life and sometimes it can develop postherpetic neuralgia (PHN). To date, it remains challenging manage well using currently available therapies. Tender point infiltration (TPI) might have the potential to be an analgesic therapy for acute and subacute HZ pain. However, current evidence remains insufficient. Therefore, the purpose of this protocol is to design a study to: 1) evaluate the analgesia efficacy and safety of TPI for acute and subacute HZ; 2) to explore the positive predictors of TPI for prevention of PHN. Methods and Analysis: This study is designed as a randomized, prospective, multicenter, blinded endpoint, open-label controlled trial including a 12-month follow-up period. 176 qualified participants will be randomly split into the standard group or TPI group in a ratio of 1:1. Primary outcome will be the presence of PHN 12 months posttreatment. Secondary outcomes include the presence of PHN at month 3 and month 6 posttreatment. Visual Analogue Scales (VAS) for assessment of pain, consumption of oral analgesia drugs, patient satisfaction scores on the 5-point Likert scale, patients' quality of life scored on the WHOQOL-BREF at day 1, week 2, month 1, month 3, month 6 and month 12, proportion of patients receiving repeated TPIs and block points each time for TPI group. Multivariable logistic analyses will be performed to identify predictive factors for the prevention of PHN at month 12 after treatment. Safety evaluation will be determined by adverse events during the trial.
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