ArticleFrontiers in pharmacology2026
7-Dehydrocholesterol attenuates osteoarthritis by synergistically inhibiting oxidative stress, inflammation, and ferroptosis in macrophages.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Research Progress on Anti-Inflammatory Adipokine SFRP5-Mediated Lipid Metabolism and Its Potential Role in Neural Development.Immunity, inflammation and disease · 2026Pooled it
- Research progress of cuproptosis, ferroptosis, apoptosis, and autophagy in knee osteoarthritis.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Osteoarthritis (OA) is a prevalent degenerative disorder affecting joints, characterized by progressive cartilage deterioration, inflammation of the synovium, and structural damage to subchondral bone. Inflammation mediated by synovial macrophages is a key driver of OA progression. Emerging evidence indicates that macrophage ferroptosis in inflamed synovium plays a pivotal role in disease advancement. 7-Dehydrocholesterol (7-DHC), an endogenous sterol with potent antioxidant properties due to its conjugated diene structure, effectively inhibits lipid peroxidation and ferroptosis. This study aimed to investigate whether 7-DHC delays OA progression by suppressing oxidative stress, inflammatory responses, and ferroptosis. Methods: To explore the mechanisms underlying inflammation Results: The findings from RAW 264.7 macrophages stimulated with LPS indicated significant inhibition of ROS accumulation, downregulation of pro-inflammatory cytokines such as TNF-α and IL-1β, and normalization of ferroptosis-associated protein expression patterns after 7-DHC application. Additionally, 7-DHC markedly suppressed phosphorylation of MAPK/NF-κB pathway proteins while enhancing expression of Nrf2/HO-1 pathway proteins. Conclusion: 7-DHC exerts anti-inflammatory and antioxidant effects by inhibiting the ROS/MAPK/NF-κB pathway and activating the Nrf2/HO-1 pathway. This reduces oxidative damage, inflammation, and ferroptosis in macrophages, thereby delaying OA progression. As a promising therapeutic strategy, 7-DHC may provide new research directions and clinical translational opportunities for OA treatment.
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