ArticleFrontiers in immunology2026
Tuft-cell-derived IL-25 regulates intestinal ILC2 in response to
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Gastrointestinal tuft cells: Recent insights and next questions.Science immunology · 2026Review
- OralFrontiers in microbiology · 2026Article
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Authors and funding
8 authors.
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Abstract
Introduction: Methods: Thirty-six mice were divided into six groups: normal control (NC), isotype control (IC), infection groups at different time points (3, 7, and 14 days post-infection, designated as Inf-3d, Inf-7d, and Inf-14d, respectively), and an IL-25 blockade group (IL-25 Blk-7d, in which mice received anti-IL-25 neutralizing antibody treatment prior to Results: The results showed that the numbers of tuft cells and ILC2s in the mouse intestine increased following Discussion: These findings confirm that the activation of the tuft cell-ILC2 circuit is dependent on the regulatory role of IL-25. These findings extend the antimicrobial role of the tuft cell-ILC2 circuit beyond parasitic immunity and identify IL-25 as an essential regulatory mediator in antibacterial defense at the intestinal mucosa.
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