Evidence map›Paper›PMID 41727494›Full record

ArticleFrontiers in immunology2026

Case Report: Infant with vaccine-associated paralytic poliomyelitis unveils global disparities in care for inborn errors of immunity.

Chee Mun Chan, Elisabeth Sue Shuen Fong, Daryl Yuan Chong Yeo, Elizabeth Y Ang, Isabella Ming Zhen Liu, Hian Tat Ong, Si Min Chan, Hui-Lin Chin, Frances Shi Hui Yeap, Chee Kwang Kee and 5 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chee Mun ChanKhoo Teck Puat National University Children's Medical Institute, National University Hospital, Singapore, Singapore.
Elisabeth Sue Shuen FongKhoo Teck Puat National University Children's Medical Institute, National University Hospital, Singapore, Singapore.
Daryl Yuan Chong YeoKhoo Teck Puat National University Children's Medical Institute, National University Hospital, Singapore, Singapore.
Elizabeth Y AngKhoo Teck Puat National University Children's Medical Institute, National University Hospital, Singapore, Singapore.
Isabella Ming Zhen LiuKhoo Teck Puat National University Children's Medical Institute, National University Hospital, Singapore, Singapore.
Hian Tat OngKhoo Teck Puat National University Children's Medical Institute, National University Hospital, Singapore, Singapore.
Si Min ChanKhoo Teck Puat National University Children's Medical Institute, National University Hospital, Singapore, Singapore.
Hui-Lin ChinKhoo Teck Puat National University Children's Medical Institute, National University Hospital, Singapore, Singapore.
Frances Shi Hui YeapKhoo Teck Puat National University Children's Medical Institute, National University Hospital, Singapore, Singapore.
Chee Kwang KeeDepartment of Diagnostic Imaging, National University Hospital, Singapore, Singapore.
Teresa Shu Zhen TanKhoo Teck Puat National University Children's Medical Institute, National University Hospital, Singapore, Singapore.
Nicholas Beng Hui NgKhoo Teck Puat National University Children's Medical Institute, National University Hospital, Singapore, Singapore.
Youjia ZhongKhoo Teck Puat National University Children's Medical Institute, National University Hospital, Singapore, Singapore.
Jeremy Bingyuan LinKhoo Teck Puat National University Children's Medical Institute, National University Hospital, Singapore, Singapore.
Lydia Su Yin WongKhoo Teck Puat National University Children's Medical Institute, National University Hospital, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe combined immunodeficiency (SCID) is a life-threatening inborn error of immunity (IEI) that is potentially curable when diagnosed early but is associated with high morbidity and mortality when recognition is delayed. In settings without universal newborn screening (NBS), and where vaccination programs rely heavily on live vaccines, affected infants are at risk of preventable complications. We report an Indonesian girl, the first child of non-consanguineous parents, who at the age of three months, developed a generalized maculopapular rash, followed by febrile encephalopathy with acute flaccid paralysis and hepatomegaly at four months of age. Investigations revealed pan-hypogammaglobulinemia (IgG <1.09 g/L, IgA <0.05 g/L, IgM 0.06 g/L) and marked eosinophilia (7554 cells/uL). On transfer to Singapore, detailed immunophenotyping revealed T cell lymphocytopenia with the vast majority being 99.3% CD45RO+ on CD3+CD4+ cells, and absent B cells. The diagnosis of SCID with Omenn syndrome was made, with genetic analysis revealing compound heterozygosity for pathogenic

Indexed as

PoliomyelitisPoliovirus Vaccine, OralSevere Combined ImmunodeficiencyFemaleHumansInfantVaccinationPoliovirus Vaccine, Oralhealthcare disparityimmunodeficiencyOmenn Syndromesevere combined immunodeficiencyvaccine-associated paralytic poliomyelitis

Identifiers

PMID41727494
PMCPMC12920594

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.