Evidence map›Paper›PMID 41727492›Full record

ArticleFrontiers in immunology2026

Seizure phenotypes and short-term prognosis in neonatal lupus: a multicenter retrospective cohort in China.

Wenqiang Sun, Xinyun Jin, Yihui Li, Xue Liu, Linzhou Zhu, Minqian Zhou, Zhirong Xie, Lili Li, Yanliang Yu, Yue Jiang and 9 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

19 authors.

Wenqiang SunDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Xinyun JinSuzhou Municipal Key Laboratory of Neonatal Major Disease Rescue and Early-Life Prevention of Adult Chronic Diseases, Suzhou, China.
Yihui LiDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Xue LiuDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Linzhou ZhuSchool of Public Health, Suzhou Medical College of Soochow University, Suzhou, China.
Minqian ZhouDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Zhirong XieDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Lili LiDepartment of Neonatology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Yanliang YuDepartment of Neonatology, Shenzhen Maternity and Child Healthcare Hospital, The First School of Clinical Medicine, Southern Medical University, Shenzhen, China.
Yue JiangDepartment of Neonatology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Jinhui HuNeonatal Medical Center, Huai' an Maternity and Child Health Care Hospital, Huaian, China.
Jie HuoDepartment of Neonatology, Yangzhou Maternity and Child Health Care Hospital, Yangzhou, China.
Huawei WangDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Haifeng GengDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Wenmei LiDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Mengzhao LiDepartment of Child and Adolescent Healthcare, Children's Hospital of Soochow University, Suzhou, China.
Yuanyuan PengDepartment of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, China.
Xihui ZhouDepartment of Pediatrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xueping ZhuDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Neonatal lupus erythematosus (NLE) is an antibody-mediated autoimmune disorder that can affect neurologic outcomes. Seizures are an uncommon but clinically important phenotype. This study assessed clinical features, neuroimaging findings, and short-term outcomes in infants with NLE and seizures. Methods: We conducted a multicenter retrospective cohort study of infants with NLE admitted to seven tertiary centers in China. Infants were categorized as epileptic seizures (ES), non-epileptic CNS involvement (NE), or no CNS involvement (nCNS). Maternal characteristics and medications during pregnancy, infant clinical manifestations, laboratory indices, autoantibodies, EEG findings, and neuroimaging were extracted from medical records. Group comparisons and multivariable logistic regression were performed to identify factors associated with ES. Follow-up was conducted to 6 months of age. Results: Among 246 infants with NLE, 17 (6.91%) had seizures, 39 (15.85%) had non-seizure CNS involvement, and 190 (77.24%) had no CNS involvement. All ES infants presented with acute symptomatic seizures, predominantly focal. Neuroimaging abnormalities were common, most frequently intracranial hemorrhage. Anti-SSA/Ro positivity was universal in ES cases and significantly higher than in nCNS ( Conclusions: NLE infants with seizures often exhibit focal seizures and structural brain injury, associated with anti-SSA/Ro positivity, limited maternal HCQ exposure, and hematologic abnormalities. Despite good seizure control, developmental delay was frequent, indicating risk for adverse neurodevelopment.

Indexed as

Lupus Erythematosus, SystemicSeizuresAntibodies, AntinuclearChinaElectroencephalographyFemaleHumansHydroxychloroquineInfantInfant, NewbornMalePhenotypePregnancyPrognosisRetrospective StudiesSS-B AntigenAntibodies, AntinuclearHydroxychloroquineSS-A antibodiesSS-B Antigenautoantibodiesclinical characteristicsneonatal lupusneurodevelopmental outcomesseizures

Identifiers

PMID41727492
PMCPMC12916622

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