ArticleFrontiers in immunology2026
Impact of rice wine-steamed
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Integrated EWM-RSM optimization of wine-steaming enhances the anti-inflammatory activity ofFrontiers in chemistry · 2026Article
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Authors and funding
12 authors.
Funding
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Abstract
Introduction: Methods: The physicochemical properties of RCP and WCP were characterized using SEM, HPGPC, FT-IR, and GC-MS. Immunosuppressed mice induced by cyclophosphamide (CTX) were used as an Results: Wine processing significantly modified the polysaccharides, increasing polysaccharide content, markedly reducing molecular weight, and altering monosaccharide composition in WCP. In CTX-induced mice, WCP administration showed superior immunomodulatory effects: it significantly improved spleen and thymus indices, elevated serum IL-2, IFN-γ, IgA, and IgM levels, and increased the CD4+/CD8+ ratio. Furthermore, WCP restored CTX-disturbed intestinal SCFA levels and positively modulated gut microbiota by increasing Bacteroidetes and beneficial probiotics, lowering the Discussion: Traditional rice-wine processing optimizes the molecular structure of Cistanche polysaccharides and significantly enhances their immunomodulatory efficacy in a cyclophosphamide-induced immunosuppression model. The enhanced activity is associated with marked improvements in gut microbiota composition and systemic immune parameters, suggesting involvement of the gut-immune axis. These findings provide a scientific basis for the traditional processing method and support the further development of processed Cistanche as a potential functional food or therapeutic agent.
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Registered trials
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