ReviewFrontiers in immunology2026
Unique chicken B cell development: species-specific mechanisms and contradictory requirements of B cell receptor for post-hatched B cell development.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Advances in Poultry RNA-Omics Research: Technologies, RNA Information Layers, and Applications in Complex Traits.Animals : an open access journal from MDPI · 2026Review
- Mechanisms of probiotic action in poultry gut: Colonization resistance, bioactive metabolites, quorum sensing activity, and immunomodulation.Poultry science · 2026Review
- Multidimensional regulatory mechanisms of chicken immunity: focus on viral infection, intestinal microbiota and heat stress.Frontiers in veterinary science · 2026Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chicken B cell development represents a remarkable evolutionary divergence from mammalian paradigms, featuring unique three-stage ontogeny centered on the bursa of Fabricius, an avian-specific primary B cell lymphoid organ. Unlike mammals where B cells develop continuously in bone marrow, chickens utilize a temporally restricted program spanning pre-bursal (E5-E14), bursal (E8-hatching), and post-bursal phases (hatching-bursal involution), each characterized by distinct molecular mechanisms and anatomical sites. In this review, we documented chicken B cell development in three developmental phases (pre-bursal to post-bursal phases) and compared it with mammalian B cell development mostly in humans as a representative mammalian model. In chicken, while the embryonic bursa of Fabricius serves as the primary B cell receptor (BCR)-dependent B cell developmental organ, it also supports BCR-independent early colonization followed by extensive activation-induced cytidine deaminase (AID)-mediated gene conversion rather than V(D)J recombination for antibody diversification. Recent gene knockout studies reveal paradoxical BCR signaling requirements for post-hatched chicken B cell development, with
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