Evidence map›Paper›PMID 41727448›Full record

ArticleFrontiers in immunology2026

Myeloid-derived PD-L1 characterizes spatially organized immune architecture in colorectal cancer.

Qian Wu, Stephanie Tissot, Allyson Peddle, Ke Yin, Xavier Sagaert, Gert De Hertogh, Benyagoub Abdelkader, Ting Pu, Filip Van Herpe, André D'Hoore and 4 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qian Wu *Digestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
Stephanie TissotImmune Landscape Laboratory, Centre Thérapies Expérimentales (CTE), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Allyson PeddleDigestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
Ke YinDigestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
Xavier SagaertDepartment of Pathology, University Hospitals Leuven and KU Leuven, Leuven, Belgium.
Gert De HertoghDepartment of Pathology, University Hospitals Leuven and KU Leuven, Leuven, Belgium.
Benyagoub AbdelkaderImmune Landscape Laboratory, Centre Thérapies Expérimentales (CTE), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Ting PuDigestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
Filip Van HerpeDigestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
André D'HooreAbdominal Surgery Department, University Hospitals Leuven, Leuven, Belgium.
Sylvie RusakiewiczImmune Landscape Laboratory, Centre Thérapies Expérimentales (CTE), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Sara VerbandtDigestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
Sabine TejparDigestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
Gertjan RasschaertDigestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The tumor immune microenvironment (TIME) is highly heterogeneous and strongly influences immunotherapy outcomes and patient prognosis in colorectal cancer (CRC). In this exploratory study, we used three multiplex immunofluorescence (mIF) assays to characterize the spatial immune microenvironment associated with high CD8/PD-L1 infiltration. Methods: Three mIF assays quantified the cell densities (cells/mm Results: PD-L1 expression was predominantly driven from stromal and immune cells with enrichment at IM versus TC, particularly on CD163 Conclusions: This exploratory mIF analysis identifies PD-L1 expression predominantly on stromal and immune cells, enriched in IM, particularly on CD163

Indexed as

B7-H1 AntigenColorectal NeoplasmsTumor MicroenvironmentAntigens, CDFemaleHumansLymphocytes, Tumor-InfiltratingMacrophagesMaleTumor-Associated MacrophagesAntigens, CDB7-H1 AntigenCD274 protein, humanCD8 T lymphocytescolorectal cancerimmune checkpoint inhibitorsimmunotherapymultiplex immunofluorescencePD-L1

Identifiers

PMID41727448
PMCPMC12920468

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.