Evidence map›Paper›PMID 41727389›Full record

ArticleVideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy2026

Multidisciplinary management of bronchoesophageal fistula using adipose-derived stromal vascular fraction and platelet-rich plasma.

Joris A van Dongen, Roos E Pouw, Metin Bülbül, Hans J L Kemming, J Henk Coert, Richard van Hillegersberg

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Article in VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Joris A van DongenDepartment of Plastic, Reconstructive, and Hand Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.
Roos E PouwDepartment of Gastroenterology, University Medical Center Utrecht, Utrecht, the Netherlands.
Metin BülbülDepartment of Pulmonology, University Medical Center Utrecht, Utrecht, the Netherlands.
Hans J L KemmingDepartment of Pulmonology, University Medical Center Utrecht, Utrecht, the Netherlands.
J Henk CoertDepartment of Plastic, Reconstructive, and Hand Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.
Richard van HillegersbergDepartment of Upper Gastrointestinal Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Bronchoesophageal fistula (BEF) is a rare but life-threatening adverse event following surgery. Fistulas result in respiratory adverse events, often requiring surgical repair, which is a high-risk procedure. Therefore, minimally invasive alternatives are needed. We aimed to use adipose-derived stromal vascular fraction (SVF) to treat BEFs. Methods: We present 2 BEF cases after minimally invasive esophagectomy and gastric conduit reconstruction. During the procedure, SVF was isolated and platelet-rich plasma (PRP) obtained. In 1 case with a tracheaesophageal fistula, simultaneous bronchoscopy and endoscopy were performed to localize and treat the fistula; in the second case, only gastroscopy was performed to treat a fistula from the esophagus to the right upper lobe. During the procedures, the epithelialized fistula tract was cleared using brushing and argon plasma coagulation, followed by injection of SVF-PRP around the fistula. Closure was obtained using a through-the-scope suturing system. Results: The patients recovered well, and an esophagram 4 weeks postprocedure showed no more signs of a fistula. Currently, 7 and 4 months postprocedure, respectively, both patients are on a normal oral diet and with restored pulmonary function. Conclusions: These cases demonstrate that SVF-PRP injection combined with endoscopic closure may offer a promising minimally invasive alternative for BEF treatment.

Identifiers

PMID41727389
PMCPMC12921678

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.