ArticleACS measurement science au2026
Investigating Spectral Biomarker Candidates for Migratory Potential in Cancer Cells Using Micro-FTIR and O‑PTIR Spectroscopy.
Article in ACS measurement science au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Demystifying Experimental Parameters in Optical Photothermal Imaging in Aqueous Media.ACS omega · 2026Article
- Intrinsic OPTIR imaging and spectroscopy enable label-free monitoring of viral infection in living cells.Analytical and bioanalytical chemistry · 2026Article
- Autoencoder-Based Detection of Nanoplastics in Biological Matrices via Infrared Hyperspectral Imaging.ACS measurement science au · 2026Article
- Leveraging image processing techniques to visualize sub-cellular domains in optical photothermal infrared imaging.The Analyst · 2026Article
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7 authors.
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Abstract
Routine diagnostic practice for cancer and metastasis relies on a time-consuming staining process and the use of antibodies to detect selected molecular markers and is hence limited by a lack of real-time data and the availability of molecular information. Against this background, techniques based on rapid chemical analysis to identify migratory properties are highly desirable. Fourier-Transform Infrared (FTIR) microspectroscopy has a long history in the label-free identification of infrared marker bands for cancer detection. However, it requires extensive postprocessing of the acquired spectra, is of limited suitability for analysis in aqueous environments, and has poor spatial resolution. To overcome these challenges, we are using a new method termed Optical Photothermal Infrared (O-PTIR) spectroscopy to detect local absorption to establish potential IR tumor markers and classification models. We report on experimental outcomes using machine learning and FTIR microspectroscopy for the classification of cells and the analysis of spectral features reflecting cancer and migratory properties, comparing a commercial FTIR microspectrometer to a custom-built O-PTIR instrument dedicated to spectroscopic measurement and imaging in microfluidic channels.
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