ArticleACS measurement science au2026
Absolute Quantification and Spatial Mapping of Hyaluronic Acid in Histological Tissue Sections.
Article in ACS measurement science au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Quantitative LA-ICP-MS Imaging of Elemental Distributions with Protein Correlation in 3D Tumor Models.Analytical chemistry · 2026Article
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Authors and funding
6 authors.
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Abstract
We present an accessible methodology for the absolute quantification and spatial mapping of hyaluronic acid (HA) in paraffin-embedded tissues. Although HA plays critical roles in tissue hydration, organization, and disease progression, its local concentration and spatial distribution remain poorly defined due to the lack of quantitative measurement tools. By integrating immunofluorescence, ELISA, and image analysis our approach enables the generation of pixel-level HA concentration maps. This strategy bridges the gap between qualitative imaging modalities and bulk biochemical assays, offering both spatial resolution and quantitative data. The method is validated across multiple tissues and is robust, scalable, and readily applicable to other extracellular matrix components, offering a practical tool for studying tissue microenvironments in health, disease, and biomaterial design.
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Registered trials
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