Evidence map›Paper›PMID 41727340›Full record

ArticleNeuro-oncology advances

Single-cell RNA sequencing suggests different progenitor lineages between

Iyad Alnahhas, Allison Kayne, Mehak Majid Khan, Wenyin Shi

Abstract read
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In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Iyad AlnahhasDivision of Neuro-Oncology, Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-1719-4994
Allison KayneDepartment of Internal Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Mehak Majid KhanDepartment of Internal Medicine, Cleveland Clinic, Cleveland, Ohio, USA (M.M.K.).
Wenyin ShiDepartment of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-6336-3912

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Single-cell RNA sequencing has elucidated the heterogeneity in cancer. Single-cell glioblastoma (GBM) analyses have also proposed the resemblance of GBM cells to radial glia and outer radial glia (oRG) supporting the hypothesis that remnants of developmental tissue get reactivated in cancer. A recent study isolated neural progenitor cells (NPCs) from developing fetal human brain (gestational week 17-19) and classified NPCs based on their expression of THY1 (CD90), CD24 and EGFR. Ventricular radial glia are THY1 Methods: We aimed to apply the classification above to Results: In Conclusion:

Indexed as

EGFRGBMprogenitor cellssingle-cell sequencingTHY1

Identifiers

PMID41727340
PMCPMC12924628

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.