Multi-scale systems toxicology defines a KLF5-centered adverse outcome pathway linking DEHP exposure to pancreatic cancer progression and signaling programs relevant to therapy tolerance.

Jihao Chen, Huaxin Pang, Jundan Wang, Junhua Guo, Ting Huang, Heran Zhou

Abstract read

In one paragraph

Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Screening of core targets for Di(2-ethylhexyl) Phthalate-related gastric cancer based on machine learning, molecular docking, and SHAP analysis.PLoS computational biology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jihao Chen *Department of Oncology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Huaxin Pang *Chinese Medicine Data Center, China Academy of Chinese Medical Sciences, Beijing, China.

Jundan Wang *Department of Oncology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Junhua GuoDepartment of Oncology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Ting HuangDepartment of Oncology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Heran ZhouDepartment of Oncology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous plasticizer implicated in pancreatic carcinogenesis, yet the molecular initiating events and adverse outcome pathways (AOPs) linking exposure to disease mechanisms remain poorly resolved. In this study, we integrated a multi-scale systems toxicology framework-combining heterogeneous ensemble machine learning, Mendelian randomization (MR), molecular docking and molecular dynamics (MD), single-cell transcriptomics, and

Indexed as

di (2-ethylhexyl) phthalateKLF5pancreatic ductal adenocarcinomaphthalatesPI3K–AKT signalingsystems toxicologyTGF-β signalingtumor immune microenvironment

Identifiers

PMID41727317

DOI10.3389/fcell.2026.1769023

PMCPMC12917211

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.