Evidence map›Paper›PMID 41727281›Full record

ArticleJournal of biomedical optics2026

Robot-assisted minimally invasive photoacoustic imaging for monitoring liver ablation using diffusing fiber illumination.

Shang Gao, Xihan Ma, Yanbo Hua, Sharath Bhagavatula, Guigen Liu, Oliver Jonas, Haichong K Zhang

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shang GaoWorcester Polytechnic Institute, Department of Robotics Engineering, Worcester, Massachusetts, United States.ORCID https://orcid.org/0000-0001-9921-7899
Xihan MaWorcester Polytechnic Institute, Department of Robotics Engineering, Worcester, Massachusetts, United States.
Yanbo HuaWorcester Polytechnic Institute, Department of Robotics Engineering, Worcester, Massachusetts, United States.
Sharath BhagavatulaBrigham and Women's Hospital, Harvard Medical School, Department of Radiology, Boston, Massachusetts, United States.
Guigen LiuBrigham and Women's Hospital, Harvard Medical School, Department of Radiology, Boston, Massachusetts, United States.
Oliver JonasBrigham and Women's Hospital, Harvard Medical School, Department of Radiology, Boston, Massachusetts, United States.
Haichong K ZhangWorcester Polytechnic Institute, Department of Robotics Engineering, Worcester, Massachusetts, United States.ORCID https://orcid.org/0000-0002-1314-8456

Funding

Implantable microdevices with integrated optical imaging for high-throughput in situ tumor response and drug sensitivity measurementR37CA224144 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI JONAS, OLIVER · 2018 to 2023
$2.4M
Four-dimensional multi-modality microimaging-microdevice system for high throughput drug screening in vivoK25EB032900 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI LIU, GUIGEN · 2022 to 2025
$694k
NCI NIH HHS R37 CA224144NIBIB NIH HHS K25 EB032900
6 · The paper itself

Abstract

Significance: Accurate intraoperative assessment of ablation completeness in liver radiofrequency ablation (RFA) remains a clinical challenge, as conventional imaging lacks real-time capability to delineate necrotic boundaries. Incomplete ablation increases recurrence risk, underscoring the need for real-time, high-resolution imaging with functional tissue differentiation. Aim: We propose a robot-assisted photoacoustic (PA) imaging system employing a customized diffusing optical fiber to improve intraoperative monitoring of liver RFA. Approach: The system integrates circumferential wide-field illumination for enhanced tissue coverage with robotic automated 3D scanning and co-registered ultrasound. Spectroscopic PA imaging differentiates necrotic from viable tissue based on optical absorption, whereas a standard Hough transform algorithm suppresses fiber-induced artifacts. Validation was performed using Results: In cadaveric studies, 3D lesion mapping showed necrotic zones of Conclusions: The proposed system enables accurate, real-time visualization of ablation lesions

Indexed as

LiverPhotoacoustic TechniquesRadiofrequency AblationRobotic Surgical ProceduresAlgorithmsAnimalsEquipment DesignHumansImaging, Three-DimensionalOptical FibersSwinediffusing fiberliver ablationminimally invasivephotoacoustic imagingrobotspectral analysis

Identifiers

PMID41727281
PMCPMC12921445

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.