Serum lncRNA H19/miR-675 /PPARα expression before middle gestation and their associations with macrosomia risk in singleton pregnancies without gestational diabetes mellitus: a preliminary study.

Qiuyan Yu, Ming Min Jin, Miao Miao Ding, Bin Wei Cheng, Xiao Xia He, Xin Jun Yang

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Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Qiuyan YuDepartment of Epidemiology and Health Statistics, School of Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Ming Min JinDepartment of Epidemiology and Health Statistics, School of Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Miao Miao DingDepartment of Epidemiology and Health Statistics, School of Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Bin Wei ChengDepartment of Epidemiology and Health Statistics, School of Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Xiao Xia HeClinical Laboratory, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.

Xin Jun YangDepartment of Epidemiology and Health Statistics, School of Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The roles of maternal serum lncRNA H19, miR-675, and Methods: A nested case-control study was conducted within a prospective cohort study of 898 women with singleton pregnancies. Mothers of liveborn macrosomic newborns constituted the case group, and a random sample of mothers of the normal-birthweight newborns, matched on gestational age at blood collection and delivery date, served as controls. Serum levels of lncRNA H19, miR-675, Results: No significant differences were observed in lncRNA H19 ( Conclusions: Serum lncRNA H19 and miR-675 were not associated with macrosomia risk. Lower serum

Indexed as

Fetal MacrosomiaMicroRNAsPPAR alphaRNA, Long NoncodingAdultBiomarkersCase-Control StudiesDiabetes, GestationalFemaleGestational AgeHumansPregnancyProspective StudiesRisk FactorsBiomarkersH19 long non-coding RNAMicroRNAsMIRN675 microRNA, humanPPAR alphaPPARA protein, humanRNA, Long NoncodingLncRNA H19MacrosomiaNon-gestational diabetes mellitusPeroxisome proliferator-activated receptorsSerum biomarkers

Identifiers

PMID41727219

DOI10.7717/peerj.20793

PMCPMC12919319

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