Evidence map›Paper›PMID 41727205›Full record

ArticleFrontiers in nutrition2026

Association of plasma remnant cholesterol with cognitive function in the middle-aged and elderly Chinese adults with type 2 diabetes: a cross-sectional study.

Xiuwen Ren, Chengjun Zhang, Zhi Duan, Sen Zhao, Zhihong Zhang, Xueying Zhang, Yu Sha, Lianyun Ju, Jie Mu, Yiyao Gu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiuwen RenSchool of Public Health, Capital Medical University, Beijing, China.
Chengjun ZhangDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Zhi DuanSuzhou Research Center of Medical School, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China.
Sen ZhaoDepartment of Hematology, Beijing Anzhen Hospital, Beijing, China.
Zhihong ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Heinz Mehlhorn Academician Workstation, Hainan Medical University, Haikou, Hainan, China.
Xueying ZhangJiangsu Province Engineering Research Center of Development and Translation of Key Technologies for Chronic Disease Prevention and Control, Suzhou Vocational Health College, Suzhou, China.
Yu ShaJiangsu Province Engineering Research Center of Development and Translation of Key Technologies for Chronic Disease Prevention and Control, Suzhou Vocational Health College, Suzhou, China.
Lianyun JuJiangsu Province Engineering Research Center of Development and Translation of Key Technologies for Chronic Disease Prevention and Control, Suzhou Vocational Health College, Suzhou, China.
Jie MuSuzhou Research Center of Medical School, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China.
Yiyao GuSuzhou Research Center of Medical School, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China.
Yunyun GongSchool of Food Science and Nutrition, University of Leeds, Leeds, United Kingdom.
Linhong YuanSchool of Public Health, Capital Medical University, Beijing, China.
Xinjing GuoSchool of Public Health, Capital Medical University, Beijing, China.
Ying WangSuzhou Research Center of Medical School, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The relationship between plasma remnant cholesterol (RC) level and cognitive function in middle-aged and older Chinese adults with type 2 diabetes (T2DM) was unclear. Methods: One thousand eight hundred seventeen participants aged 55 to 75 were recruited from communities in Beijing. Demographic information and daily dietary intakes were collected by self-designed questionnaire. Fasting venous blood was obtained for quantitative analysis of plasma lipid parameters. The Montreal Cognitive Assessment (MoCA) was used to assess cognitive function. To explore the association between plasma RC and the risk of mild cognitive impairment (MCI), we performed logistic regression analysis and restricted cubic spline (RCS). Additionally, subgroup analyses were conducted to assess the influence of potential co-founders on the association. Results: Plasma RC level was negatively correlated with daily intakes of vegetable, legume and fish intakes in patients with T2DM, and with daily intakes of cereals, vegetables, and legumes in non-T2DM subjects. Participants with plasma RC levels in the second (Q Conclusion: An increase in plasma RC level is a potential risk factor for MCI. A plasma RC concentration below 0.578 mmol/L can decrease the risk of MCI in middle-aged and older individuals with T2DM. Similarly, a plasma RC concentration below 0.581 mmol/L may lower the risk of MCI in non-T2DM subjects. Consuming vegetables and legumes daily could help reduce the concentration of RC.

Indexed as

dietarymiddle-aged and older adultsmild cognitive impairmentremnant cholesteroltype 2 diabetes mellitus

Identifiers

PMID41727205
PMCPMC12922238

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.