Evidence map›Paper›PMID 41727181›Full record

ArticleiScience2026

Single-cell transcriptomics revealed molecular vulnerability in a human midbrain-like organoid model of Parkinson's disease.

Jessica Jiaxin Xie, Matas Vitkauskas, Quyen Do, Tzuen Yih Saw, Alfred Xuyang Sun, Lin Yang, Tuck Wah Soong, Kah-Leong Lim, Eng-King Tan, Huck-Hui Ng and 1 more

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jessica Jiaxin XieGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore.
Matas VitkauskasGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore.
Quyen DoGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore.
Tzuen Yih SawGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore.
Alfred Xuyang SunGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore.
Lin YangGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore.
Tuck Wah SoongDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Kah-Leong LimDepartment of Neurology, National Neuroscience Institute (Singapore General Hospital Campus), Singapore 308433, Singapore.
Eng-King TanDepartment of Neurology, National Neuroscience Institute (Singapore General Hospital Campus), Singapore 308433, Singapore.
Huck-Hui NgGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore.
Jinyue LiuGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human midbrain-like organoid (hMLO) is a key model system for investigating pathological features of Parkinson's disease (PD), yet how its molecular landscape relates to cellular vulnerability in PD remains unclear. We performed in-depth single-cell characterization of our previously established hMLO model up to 150 days

Indexed as

DiseaseIntegrative aspects of cell biologyMolecular neuroscienceTranscriptomics

Identifiers

PMID41727181
PMCPMC12918236

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.