Evidence map›Paper›PMID 41727168›Full record

ArticlebioRxiv : the preprint server for biology2026

β-strand complementation within tip initiation complexes licenses assembly of diverse type IV filaments.

Taylor J Ellison, Zoey R Litt, Justin N Applegate, Emma Miller, Luther Davis, Alfredo Ruiz-Rivera, Angela Lisovsky, Rittika Saha, Naveen Jasti, Stephanie McLaughlin and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Taylor J EllisonDepartment of Microbiology, University of Georgia.
Zoey R LittDepartment of Biochemistry, University of Washington.ORCID 0009-0000-6513-7583
Justin N ApplegateDepartment of Biochemistry, University of Washington.ORCID 0000-0002-2508-9190
Emma MillerDepartment of Biochemistry, University of Washington.
Luther DavisDepartment of Biochemistry, University of Washington.ORCID 0000-0002-2346-3898
Alfredo Ruiz-RiveraDepartment of Biochemistry, University of Washington.ORCID 0000-0002-4823-8056
Angela LisovskyDepartment of Biochemistry, University of Washington.ORCID 0009-0007-8594-8309
Rittika SahaDepartment of Biochemistry, University of Washington.ORCID 0009-0003-7001-0028
Naveen JastiDepartment of Biochemistry, University of Washington.ORCID 0000-0003-1444-7543
Stephanie McLaughlinDepartment of Biochemistry, University of Washington.ORCID 0000-0002-6658-8260
Beth TraxlerDepartment of Microbiology, University of Washington.ORCID 0009-0004-7462-370X
Courtney K EllisonDepartment of Microbiology, University of Georgia.ORCID 0000-0003-3259-079X
Alexey J MerzDepartment of Biochemistry, University of Washington.ORCID 0000-0003-2177-6492

Funding

University of Washington Medical Scientist Training Program: MD/PhDT32GM007266 · NIGMS · UNIVERSITY OF WASHINGTON · PI HORWITZ, MARSHALL S. · 1985 to 2023
$30.4M
University of Washington Medical Scientist Training ProgramT32GM153182 · NIGMS · UNIVERSITY OF WASHINGTON · PI MARSHALL S. HORWITZ · 2024 to 2026
$5.3M
Mechanism of the Fluoroquinolone Resistance Acquisition in EnterobacteriaR01AI150152 · NIAID · UNIVERSITY OF WASHINGTON · PI SOKURENKO, EVGENI VENIAMINOVIC, TRAXLER, BETH A · 2021 to 2025
$3.6M
Molecular Biophysics Training ProgramT32GM153507 · NIGMS · UNIVERSITY OF WASHINGTON · PI Charles L Asbury, Justin M Kollman · 2024 to 2026
$1.7M
Molecular mechanisms of physical interactions between bacteria and their surroundingsR35GM150916 · NIGMS · UNIVERSITY OF GEORGIA · PI Courtney Kathleen Ellison · 2023 to 2026
$1.5M
MOLECULAR BASIS OF PILUS-MEDIATED GONOCOCCAL ADHESIONR21AI155991 · NIAID · UNIVERSITY OF WASHINGTON · PI MERZ, ALEXEY JARRELL · 2021 to 2022
$428k
MECHANISMS IN MICROBIAL PATHOGENESIST32AI007410 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MEKALANOS, JOHN J · 1992 to 2001
$345k
NIAID NIH HHS R01 AI150152NIAID NIH HHS R21 AI155991NIAID NIH HHS T32 AI007410NIGMS NIH HHS R35 GM150916NIGMS NIH HHS T32 GM007266NIGMS NIH HHS T32 GM153182NIGMS NIH HHS T32 GM153507
6 · The paper itself

Abstract

PilC/PilY1 proteins are tip-located adhesins of type IV pili (T4P) that are critical for T4P function in diverse behaviors including twitching motility, DNA uptake, and host cell adhesion. PilC and PilY1 adhesins are proposed to interact with initiation complexes composed of minor pilins (PilIJK family proteins) to aid in initiation of T4P polymerization, but it has been unclear how PilC/PilY1 proteins promote fiber assembly. We combined structural modeling, genetic, and biochemical experiments using

Identifiers

PMID41727168
PMCPMC12918778

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.