Cognition, but not affect, rests upon a segregated intrinsic network architecture.

The brain's intrinsic organization into resting-state networks has long been suggested to be fundamental for the offline support of mental processes. Extensive task-based evidence support the relevance of the crosstalk between network segregation, supporting systems specialization, and network integration, allowing to flexibly implement complex behavior. However, only scarce evidence focusing on few behavioral measures directly link changes in these network properties at rest with interindividual differences in behavior. In this work, we investigated whether the maintenance of behavior is associated with a segregated intrinsic resting-state networks organization. Using a comprehensive set of behavioral measures spanning cognition, emotion, and personality together with resting-state functional magnetic resonance imaging from the human connectome project, we performed functional connectivity prediction of behavior combined with model interpretability and latent connectivity-behavior factors extraction. We then assessed whether connectivity-behavior patterns were associated with changes in segregation or integration based on GINNA, a 33 resting-state-networks atlas with cognitive characterization, providing opportunities for comparison of the involved cognitive processes. We found that connectivity relevant for behavior organizes into 3 main latent dimensions, summarizing