Evidence map›Paper›PMID 41727129›Full record

ArticlebioRxiv : the preprint server for biology2026

2-Deoxyglucose dendrimer-enabled niclosamide delivery to FRβ-expressing macrophages alleviates endometriosis progression and associated hyperalgesia.

Anubhav Dhull, Mingxin Shi, Madeleine E Harvey, Taylor M Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S Moawad, Vijay Kumar Sirohi, Paul S Cooke and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Anubhav DhullDepartment of Chemistry, College of Arts and Sciences, Washington State University, Pullman, WA 99164, USA.
Mingxin ShiSchool of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA.ORCID 0000-0003-3390-8827
Madeleine E HarveySchool of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA.ORCID 0000-0001-6257-2918
Taylor M PageSchool of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA.
Rishi SharmaDepartment of Chemistry, College of Arts and Sciences, Washington State University, Pullman, WA 99164, USA.
Kenneth John GoodyDepartment of Chemistry, College of Arts and Sciences, Washington State University, Pullman, WA 99164, USA.
Aqib Iqbal DarDepartment of Chemistry, College of Arts and Sciences, Washington State University, Pullman, WA 99164, USA.
Nash S MoawadDepartment of Obstetrics & Gynecology, University of Florida College of Medicine, P.O. Box 100294, Gainesville, FL 32610, USA.
Vijay Kumar SirohiDepartment of Physiological Sciences, University of Florida, P.O. Box 100144, Gainesville, FL 32611, USA.
Paul S CookeDepartment of Physiological Sciences, University of Florida, P.O. Box 100144, Gainesville, FL 32611, USA.
Kanako HayashiSchool of Molecular Biosciences, Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA.ORCID 0000-0002-5028-799X
Anjali SharmaDepartment of Chemistry, College of Arts and Sciences, Washington State University, Pullman, WA 99164, USA.

Funding

Complex inflammatory mechanisms and therapeutic targeting in endometriosisR01HD104619 · NICHD · WASHINGTON STATE UNIVERSITY · PI HAYASHI, KANAKO · 2021 to 2025
$2.4M
NICHD NIH HHS R01 HD104619
6 · The paper itself

Abstract

Endometriosis is a chronic, incurable disease. Due to limited efficacy, high recurrence rates, and serious side effects of current treatments, development of new, targeted, non-hormonal therapies is urgently needed. We previously reported that niclosamide, an FDA-approved anthelmintic drug, attenuates endometriotic lesion growth. We further identified folate receptor-β (FRβ)-positive macrophages as contributors to disease progression. Significantly, niclosamide inhibits FRβ

Indexed as

dendrimerendometriosismacrophagesniclosamidenon-hormonal therapy

Identifiers

PMID41727129
PMCPMC12918866

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.